Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Review Article Volume 7 Issue 4

Study of the Interrelationship Between Irritable Bowel Syndrome and Hypothyroidism

Bijoya Bhattacharjee*1,2, Swarna Upadhyay2 and Joyeta Ghosh2

1*,2Department of Dietetics and Applied Nutrition, Amity Institute of Applied Sciences (AIAS), Amity 1*Department of Food and Nutrition, Swami Vivekananda University, Barrackpore, West Bengal, Kolkata

*Corresponding Author: Bijoya Bhattacharjee, Department of Dietetics and Applied Nutrition, Amity Institute of Applied Sciences (AIAS), Amity University, Kolkata, West Bengal, India; Department of Food and Nutrition, Swami Vivekananda University, Barrackpore, West Bengal, Kolkata

Received: March 20, 2023; Published: March 23, 2023


Irritable bowel syndrome (IBS) is becoming popular health problem day by day. Report shows that around15 to 25% of the world population suffers from IBS. There is lack of evidences where gastrointestinal manifestation is reported with thyroid dysfunctional state, yet in this regard gastrointestinal motor dysfunction, predisposes with altered intestinal motility as well as transit time, has been accepted as the leading cause of gastrointestinal symptoms of thyroid disease. Research shows that patients having hypothyroidism may also experience frequent bowel movements, diarrhea, along with malabsorption and steatorrhea. epigastric pain and fullness etc such chronic dyspeptic symptoms as well as eructation, nausea and vomiting are also frequently observed among such patients. After all it is still not clear whether thyroid disorder can be considered in the differential diagnosis of patients with IBS symptoms or not. Hence in present review the objective was to understand the interrelationship between irritable bowel syndrome and hypothyroidism. The routine thyroid function tests in the diagnostic evaluation of established IBS patients should be recommended since it has been observed that hypothyroid patients have a great risk of developing IBS in the long run. More elaborative evidence based research is required to understand the relationship clearly.

Keywords: Irritable bowel syndrome, gut microbiome, psychosocial status, GI motility.


  1. Thompson WG. “A world view of IBS”. In: Irritable Bowel Syndrome: Diagnosis and Treatment. 1st Camilleri M and Spiller R (eds). Saunders, New York, NY (2002): 17-26.
  2. Everhart JE and Renault PF. “Irritable bowel syndrome in office based practice in the United States”. Gastroenterology 100 (1991): 998-1005.
  3. Thompson WG., et al. “Irritable bowel syndrome: guidelines for the diagnosis”. Gastroenterology International 2 (1989): 92-95.
  4. Drossman DA., et al. “Identifications of subgroups of functional gastrointestinal disorders”. Gastroenterology International 3 (1990): 159-172.
  5. Wegener M., et al. “Effect of hyperthyroidism on the transit of a caloric solid liquid meal through the stomach, the small intestine, and the colon in man”. The Journal of Clinical Endocrinology and Metabolism 75 (1992): 745749.
  6. Tinker MB. “Discussion of paper by Verbrycke JR. Masked gastrointestinal hyperthyroidism”. JAMA 97 (1931): 515-516.
  7. Karaus M., et al. “Intestinal motor activity in experimental hyperthyroidism in conscious dogs”. Gastroenterology 97 (1989): 911-919.
  8. Hoogendoorn EH and Cools BM. “Hyperthyroidism as a cause of persistent vomiting”. Netherlands Journal of Medicine 62 (2004): 293-296.
  9. Bassotti G., et al. “Intestinal pseudo obstruction secondary to hypothyroidism. Importance of small bowel manometry”. Journal of Clinical Gastroenterology 14 (1992): 56-58.
  10. Cash BD., et al. “The utility of diagnostic tests in irritable bowel syndrome patients: a systematic review”. American Journal of Gastroenterology 97 (2002): 28129.
  11. Surdea-Blaga T., et al. “Psychosocial determinants of irritable bowel syndrome”. World Journal of Gastroenterology 7 (2012): 616-626.
  12. Mudyanadzo T A., et al. “Irritable bowel syndrome and Depression: A Shared Pathogenesis”. Cureus 8 (2018): e3178.
  13. Chong PP., et al. “The Microbiome and Irritable Bowel Syndrome - A Review on the Pathophysiology, Current Research and Future Therapy”. Frontiers in Microbiology 10 (2019): 1136.
  14. Raffaele Borghini., et al. “New insights in IBS-like disorders: Pandora's box has been opened; a review”. (2017).
  15. William D Chey., et al. “Irritable bowel syndrome: a clinical review”. JAMA9 (2015): 949-958.
  16. Foster JA and McVey Neufeld KA. “Gut-brain axis: how the microbiome influences anxiety and depression”. Trends in Neuroscience 36 (2013): 305-312.
  17. Eugenio MD., et al. “Comprehensive self-management reduces the negative impact of irritable bowel syndrome symptoms on sexual functioning”. Digestive Diseases and Sciences 6 (2012): 1636-1646.
  18. Kostoglou-Athanassiou I and Ntalles K. “Hypothyroidism - new aspects of an old disease”. Hippokratia2 (2010): 82-87.
  19. Kirsten Jackson Consultant Dietitian BSc Hons, RD, PG Can Hypothyroidism Cause IBS? - THE IBS DIETITIAN (
  20. Mohan Khadka., et al. “Prevalence of Thyroid Dysfunction in Irritable Bowel Syndrome”. January 2018 Journal of Universal College of Medical Sciences2:1.
  21. M Bauer., et al. “Thyroid hormones, serotonin and mood: of synergy and significance in the adult brain”. Molecular Psychiatry 7 (2002): 140-156.
  22. Caron P., et al. “Factors influencing the levothyroxine dose in the hormone replacement therapy of primary hypothyroidism in adults”. Reviews in Endocrine and Metabolic Disorders 23 (2022): 463-483.
  23. Rok Son Choung., et al. “Food Allergy and Intolerance in IBS”. Gastroenterology and Hepatology10 (2006): 756-760.
  24. Sanyal D and Raychaudhuri M. “Hypothyroidism and obesity: An intriguing link”. Indian Journal of Endocrinology and Metabolism 4 (2016): 554-557.
  25. Octavia Pickett-Blakely MD MHS. “Obesity and irritable bowel syndrome: a comprehensive review”. Gastroenterology and Hepatology 7 (2014): 411-416.
  26. Susanna C Wiens and Vance L Trudeau. “Thyroid hormone and gamma-aminobutyric acid (GABA) interactions in neuroendocrine systems”. Comparative Biochemistry and Physiology. Part A, Molecular and Integrative Physiology 3 (2006): 332-344.
  27. Monica Gros., et al. “Neurotransmitter Dysfunction in Irritable Bowel Syndrome: Emerging Approaches for Management”. Journal of Clinical Medicine15 (2021): 3429.
  28. Heinrich TW and Grahm G. “Hypothyroidism Presenting as Psychosis: Myxedema Madness Revisited”. Primary Care Companion to the Journal of Clinical Psychiatry 6 (2003): 260-266.
  29. Hüsamettin Erdamar., et al. “The effect of hypothyroidism, hyperthyroidism, and their treatment on parameters of oxidative stress and antioxidant status”. Clinical Chemistry and Laboratory Medicine (2008).
  30. William C Lloyd III, MD, FACS Written By Diana Kelly. “How Does Stress Affect Hypothyroidism?” Updated on January 17, (2021).
  31. Tang R., et al. “Subclinical Hypothyroidism and Depression: A Systematic Review and Meta-Analysis”. Frontiers in Endocrinology (Lausanne) 10 (2021):
  32. Dinan TG., et al. “Psychobiotics: a novel class of psychotropic”. Biological Psychiatry 74 (2013): 72.
  33. Ait-Belgnaoui A., et al. “Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats”. Psychoneuroendocrinology 37 (2012): 1885-1895.
  34. Neufeld KM., et al. “Reduced anxiety-like behavior and central neurochemical change in germ-free mice”. Neurogastroenterology and Motility 23 (2011): 264, e119.
  35. Zhou L and Foster J. “Psychobiotics and the gut-brain axis: in the pursuit of happiness”. Neuropsychiatric Disease and Treatment (2015): 715.
  36. Sudo N., et al. “Postnatal microbial colonization programs the hypothalamic-pituitary adrenal system for stress response in mice”. Journal of Physiology-London 558 (2004): 263-275.
  37. Shan Liang., et al. “Recognizing Depression from the Microbiota–Gut–Brain Axis”. International Journal of Molecular Sciences 6 (2018): 1592.
  38. Daulatzai MA. “Non-celiac gluten sensitivity triggers gut dysbiosis, neuron inflammation, gut-brain axis dysfunction, and vulnerability for dementia”. CNS and Neurological Disorders - Drug Targets 14 (2015): 110-131.
  39. Ping-Huei Tseng., et al. “Obesity Exacerbates Irritable Bowel Syndrome-Related Sleep and Psychiatric Disorders in Women With Polycystic Ovary Syndrome.
  40. Aziz MNM., et al. “Irritable Bowel Syndrome, Depression, and Neurodegeneration: A Bidirectional Communication from Gut to Brain”. Nutrients9 (2021): 3061.
  41. , et al. “Prevalence of Constipation and its Relationship with Dietary Habits Among College Going Girls in the Age Group of 18-25 Years of Kolkata, West Bengal, India”. Acta Scientific Gastrointestinal Disorders 6.3 (2023): 03-13.
  42. Bhattacharjee., et al. ”Study of Interrelationship Between Irritable Bowel Syndrome and Non-Alcoholic Fatty Liver Disease”. Acta Scientific Gastrointestinal Disorders 6.4 (2023): 08-17.


Citation: Bijoya Bhattacharjee., et al. “Study of the Interrelationship Between Irritable Bowel Syndrome and Hypothyroidism”.Acta Scientific Medical Sciences 7.4 (2023): 165-172.


Copyright: © 2023 Bijoya Bhattacharjee., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.403

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is June 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US