Urinary Adiponectin as a Predictor of Carotid Atherosclerosis in
Metabolic Syndrome Patients with or without Type 2 Diabetes Mellitus
Ismail Dahashan1, Hassan Shora2*, Nada Ahmed3 and Seham Ibrahim1
1Family Medicine Department, Faculty of Medicine, Suez Canal University, Egypt
2Biochemistry Department, Faculty of Medicine, Port-Said University, Egypt
3Clinical Pathology Department, Faculty of Medicine, Suez Canal University
*Corresponding Author: Hassan A Shora, Senior Research Scientist, Head of Medicine and Diabetes Center, Port-Said University and Ismailia Medical Complex, Egypt.
January 05, 2023; Published: January 20, 2023
Background: Long-term research into adiponectin and other adipose tissue hormones as a biomarker for atherosclerotic changes in cardiometabolic and type 2 diabetes patients has shown mixed findings. This study aimed for evaluating urinary adiponectin (uAPN) as a potential biomarker for prediction of carotid atherosclerosis in metabolic syndrome patients with or without type 2 diabetes mellitus.
Subjects and Methods: This study recruited 220 participants from patients attending Endocrine and Diabetes outpatient centre in Ismailia Medical complex who were assigned into four groups, each had 55 participants: control, non-diabetic cardiometabolic, diabetic non-cardiometabolic, and diabetic cardiometabolic group. Urine and venous blood samples were collected to measure urinary and plasma adiponectin as well as other common blood assays according to the standard methods. Carotid Ultrasonography was performed to estimate carotid plaque score (CPS).
Results: Compared with control group, urinary adiponectin concentration was significantly higher in the three cardiometabolic and diabetic groups with values 7 ± 2.7, 6.6 ± 2.9, and 9.3 ± 3.9, respectively. Carotid plaque scores as median (IQR) showed a progressively higher value from group 1 to group 4 with statistically significant differences between the 4 groups. The results of the multivariate linear regression analysis for the prediction of CPS showed a highly statistically significant Beta of 39% for urinary adiponectin. ROC curve analysis for the performance of urinary adiponectin level as a diagnostic test for prediction of above median CPS showed a significant cut-off value of 6.42 ng/mg creatinine, with and a sensitivity of 85.8%, and specificity of 82.2%.
Conclusion: In the absence of additional controlled research, the measurement of urine adiponectin excretion is thought to be a credible urine biomarker for assessing higher risk of vascular events in people with type 2 diabetes and cardiometabolic disease.
Keywords: Urinary Adiponectin; Cardiometabolic Syndrome Carotid Plaque Score; Type 2 Diabetes
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