Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Research Article Volume 6 Issue 12

Oservational Study of Two Cases of Macrophagic Activation Syndrome in the General Pediatric Department of the Marc Jacquet Melun Hospital Center

Bangoura K1,3*, Diallo FB2, Diallo ML2, Camara SH2, Conde I2 and Kouyate M2

1Pediatric Ward, Marc Jacquet, Guinea
2Pediatric Ward, CHU Donka, Guinea
3Gamal Abdel Nasser University Conakry, Guinea

*Corresponding Author: Bangoura K, Pediatric Ward, Marc Jacquet, Guinea.

Received: November 03, 2022; Published: November 23, 2022

Abstract

Macrophage activation syndrome is a pathology whose diagnosis is difficult because of its rarity, its clinical variability and the absence of a specific diagnostic test. However, the delay in diagnosis weighs its prognosis.

This syndrome can be primary in children or secondary to various infections at any age. Viral infections by herpes virus (especially Epstein Barr and cytomegalovirus), by intracellular germs but also by pyogenic bacteria or with neoplasia (mainly lymphoma) and certain autoimmune diseases (lupus and still) [1].

It is characterized by a set of non-specific clinical and biological signs but the association of which should suggest the diagnosis and lead to a cytological or histological examination to confirm it.

In this observation, our objectives were to reduce the time to diagnosis and review our decision tree in the case of fever in children.

This was a single-center retrospective study of cases diagnosed with macrophage activation syndrome hospitalized in the general pediatrics department for 10 years.

Diagnosis was based on clinical and paraclinical examination of suspected cases of macrophage activation syndrome with case selection criteria.

For both patients, we calculated the macrophage activation syndrome score established by the Saint Antoine team. On admission and at diagnosis.

Patient 1 presented 5 criteria according to Henter while patient 2 presented only 4 for the diagnosis of macrophage activation syndrome. However, these criteria experienced a temporal dispersion. The diagnoses were evoked by the clinical and paraclinical aspect. However, in the absence of hemophagocytosis, the differential diagnosis is made with other diseases and is often difficult.

Keywords: Syndrome; Activation; Macrophasic; Diagnosis

References

  1. Lindemann TL and Greene JS. “Persistent cervical lymphadenopathy in a year adolescent with Epstein-Barr induced hemophagocytic syndrome : manifestations of a rare but often fatal disease”. International Journal of Pediatric Otorhinolaryngology 7 (2005): 1011-1014.
  2. Janka GE. “Hemophagocytic syndromes”. Blood Review5 (2007): 245-253.
  3. Lambotte O and Méchaï F. “Macrophage activation syndrome”. The letter from the Infectiologist XXII.3 (2007).
  4. Henter JI., et al. “Diagnostic and therapeutic guidelines for emophagocytic lymphohistiocytosis”. Pediatric Blood Cancer2 (2007): 124-131.
  5. Pasic S., et al. “Epstein-Barr virus-associated haemophagocytic lymphohistiocytosis in Wiskott-Aldrich syndrome”. Acta Paediatrics7 (2003): 859-861.
  6. Rigande D and Esposito S. “A roadmap for fever of unknown origin in children”. International Journal of Immunopathology and Pharmacology 26 (2013): 315-326.
  7. Mcarthy P. “Fever without apparent source on clinical examination”. Current Opinion in Pediatrics 17 (2005): 93-110.
  8. Seashore CJ and Lohr JA. “Fever of unknown origin in children”. Annals of Pediatrics 40 (2011): 26-30.
  9. Marshall GS. “Prolonged and recurrent fevers”. Journal of Infection 68 (2014): 583-593.

Citation

Citation: Bangoura K., et al. “Oservational Study of Two Cases of Macrophagic Activation Syndrome in the General Pediatric Department of the Marc Jacquet Melun Hospital Center”.Acta Scientific Medical Sciences 6.12 (2022): 71-79.

Copyright

Copyright: © 2022 Bangoura K., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.403

Indexed In





News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is February 15, 2023.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US