Bangoura K1,3*, Diallo FB2, Diallo ML2, Camara SH2, Conde I2 and Kouyate M2
1Pediatric Ward, Marc Jacquet, Guinea
2Pediatric Ward, CHU Donka, Guinea
3Gamal Abdel Nasser University Conakry, Guinea
*Corresponding Author: Bangoura K, Pediatric Ward, Marc Jacquet, Guinea.
Received: November 03, 2022; Published: November 23, 2022
Macrophage activation syndrome is a pathology whose diagnosis is difficult because of its rarity, its clinical variability and the absence of a specific diagnostic test. However, the delay in diagnosis weighs its prognosis.
This syndrome can be primary in children or secondary to various infections at any age. Viral infections by herpes virus (especially Epstein Barr and cytomegalovirus), by intracellular germs but also by pyogenic bacteria or with neoplasia (mainly lymphoma) and certain autoimmune diseases (lupus and still) .
It is characterized by a set of non-specific clinical and biological signs but the association of which should suggest the diagnosis and lead to a cytological or histological examination to confirm it.
In this observation, our objectives were to reduce the time to diagnosis and review our decision tree in the case of fever in children.
This was a single-center retrospective study of cases diagnosed with macrophage activation syndrome hospitalized in the general pediatrics department for 10 years.
Diagnosis was based on clinical and paraclinical examination of suspected cases of macrophage activation syndrome with case selection criteria.
For both patients, we calculated the macrophage activation syndrome score established by the Saint Antoine team. On admission and at diagnosis.
Patient 1 presented 5 criteria according to Henter while patient 2 presented only 4 for the diagnosis of macrophage activation syndrome. However, these criteria experienced a temporal dispersion. The diagnoses were evoked by the clinical and paraclinical aspect. However, in the absence of hemophagocytosis, the differential diagnosis is made with other diseases and is often difficult.
Keywords: Syndrome; Activation; Macrophasic; Diagnosis
Citation: Bangoura K., et al. “Oservational Study of Two Cases of Macrophagic Activation Syndrome in the General Pediatric Department of the Marc Jacquet Melun Hospital Center”.Acta Scientific Medical Sciences 6.12 (2022): 71-79.
Copyright: © 2022 Bangoura K., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.