Jasmin K Khatri¹*, Suhas R Pednekar², Ramesh S Chaughule¹

¹Organic Chemistry Research Laboratory, Ramnarain Ruia Autonomous College, Mumbai, India
²Vice-chancellor, University of Mumbai, Kalina Campus, Mumbai, India

*Corresponding Author: Jasmin K Khatri, Organic Chemistry Research Laboratory, Ramnarain Ruia Autonomous College, Mumbai, India.

Received: July 14, 2022; Published: August 01, 2022

Abstract

Benzodiazepine-2-one moiety consists of a seven-member heterocyclic ring, a derivative of benzodiazepine group, which is a class of medications that works in the central nervous system and used for a variety of medical conditions, such as anxiety, seizures, and alcohol withdrawal. Microwave-assisted synthesis of certain medically important benzodiazepin-2-ones was carried out using hexamine and ammonium chloride starting from 2-aminobenzophenones. Feasibility and optimization of the reaction conditions under closed vessel CEM microwave synthesizer provide the desired product with excellent yields (~90%), within minutes of focused microwave irradiation, without the use of catalyst, thereby, revealing the benefit of saving energy and time.

Keywords: Microwave Synthesizer; Cyclization, Benzodiazepin-2-one; Hexamine; Focused Microwave Irradiation; Pharmacologica

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Citation

Citation: Jasmin K Khatri., et al. “Energy Efficient Synthesis of Various Pharmaceutically Important Benzodiazepin-2-ones Using Microwave Synthesizer”.Acta Scientific Medical Sciences 6.9 (2022): 03-08.

Copyright

Copyright: © 2022 Jasmin K Khatri., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.