Nada Jnyah*, Hadjarath Dambaba, Chaimae Soltani, Basmat Amal Chouhani, Ghita El Bardai, Nadia Kabbali and Tarik Sqalli Houssaini

Nephrology Department, CHU Hassan II of Fez, Morocco

*Corresponding Author: Nada Jnyah, Nephrology Department, CHU Hassan II of Fez, Morocco.

Received: December 07, 2021; Published: March 11, 2022

Abstract

Introduction: The American College of Rheumatology (ACR), the Systemic Lupus International Clinics (SLICC) group and the European Alliance of Associations for Rheumatology (EULAR) are three classifications for diagnosing systemic lupus erythematosus with different sensitivities and specificities.

Purpose of the study: Our purpose is to compare the sensitivity of these scores in the diagnosis of lupus to adopt the most relevant classification in our daily practice.

Materials and Methods: We conducted a prospective descriptive and analytical study including renal biopsies objectifying a lupus nephritis. These biopsies were performed in the nephrology department of the University hospital center Hassan II of Fes, from January 2010 to January 2021 to compare the sensitivity of these scores. Biopsies made during a relapse were excluded. Patient data was collected from records and computerized management software. Socio-demographic, clinical-biological and immunological data were processed by the SPSS software. The reference test of the calculation of sensitivity considered the decision of the medical staff, which is a daily meeting in the nephrology department, it aims to discuss the files of patients hospitalized and seen during night shift by doctors in training. This meeting is held under the aegis of four professors of nephrology, two of them are associate professors and two assistants. The decision of the medical staff to define lupus patients is based on a bundle of clinical biological, immunological, and pathological arguments.

Results Achieved: We collected 183 patients with an average age of 38.4 years with a standard deviation of 12.9 [17-76 years]. One hundred and sixty-seven (167) patients (91.3%) of the sample studied validate 4 out of 11 criteria of the ACR, with a sensitivity of 97%. For SLICC, 163 patients (89%) meet 4 out of 17 criteria, compared to 155 patients (84.7%) for EULAR. Thus, the sensitivity is 97% for the ACR, 96% for the SLICC and 93% for the EULAR classification with positive predictive values of 87.7%, 86.3% and 89% respectively.

The changes made by SLICC, and EULAR classification allowed to obtain 90 patients (49.2%) and 126 patients (68.9%) meeting the joint criterion respectively compared to 37 (20.2%) only for ACR. Following these same changes, 35 patients (19.1%) meet the neurological criterion of SLICC compared to 25 (13.7%) for ACR and EULAR.

Conclusion: The EULAR classification loses its sensitivity but gains its predictive value.

Keywords: Lupus; ACR; SLICC; EULAR; Sensitivity

References

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Citation

Citation: Nada Jnyah., et al. “ACR, SLICC, EULAR: Which Sensitivities in the Diagnosis of Lupus?”.Acta Scientific Medical Sciences 6.4 (2022): 69-72.

Copyright

Copyright: © 2022 Nada Jnyah., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.