Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Research Article Volume 6 Issue 4

ACR, SLICC, EULAR: Which Sensitivities in the Diagnosis of Lupus?

Nada Jnyah*, Hadjarath Dambaba, Chaimae Soltani, Basmat Amal Chouhani, Ghita El Bardai, Nadia Kabbali and Tarik Sqalli Houssaini

Nephrology Department, CHU Hassan II of Fez, Morocco

*Corresponding Author: Nada Jnyah, Nephrology Department, CHU Hassan II of Fez, Morocco.

Received: December 07, 2021; Published: March 11, 2022


Introduction: The American College of Rheumatology (ACR), the Systemic Lupus International Clinics (SLICC) group and the European Alliance of Associations for Rheumatology (EULAR) are three classifications for diagnosing systemic lupus erythematosus with different sensitivities and specificities.

Purpose of the study: Our purpose is to compare the sensitivity of these scores in the diagnosis of lupus to adopt the most relevant classification in our daily practice.

Materials and Methods: We conducted a prospective descriptive and analytical study including renal biopsies objectifying a lupus nephritis. These biopsies were performed in the nephrology department of the University hospital center Hassan II of Fes, from January 2010 to January 2021 to compare the sensitivity of these scores. Biopsies made during a relapse were excluded. Patient data was collected from records and computerized management software. Socio-demographic, clinical-biological and immunological data were processed by the SPSS software. The reference test of the calculation of sensitivity considered the decision of the medical staff, which is a daily meeting in the nephrology department, it aims to discuss the files of patients hospitalized and seen during night shift by doctors in training. This meeting is held under the aegis of four professors of nephrology, two of them are associate professors and two assistants. The decision of the medical staff to define lupus patients is based on a bundle of clinical biological, immunological, and pathological arguments.

Results Achieved: We collected 183 patients with an average age of 38.4 years with a standard deviation of 12.9 [17-76 years]. One hundred and sixty-seven (167) patients (91.3%) of the sample studied validate 4 out of 11 criteria of the ACR, with a sensitivity of 97%. For SLICC, 163 patients (89%) meet 4 out of 17 criteria, compared to 155 patients (84.7%) for EULAR. Thus, the sensitivity is 97% for the ACR, 96% for the SLICC and 93% for the EULAR classification with positive predictive values of 87.7%, 86.3% and 89% respectively.

The changes made by SLICC, and EULAR classification allowed to obtain 90 patients (49.2%) and 126 patients (68.9%) meeting the joint criterion respectively compared to 37 (20.2%) only for ACR. Following these same changes, 35 patients (19.1%) meet the neurological criterion of SLICC compared to 25 (13.7%) for ACR and EULAR.

Conclusion: The EULAR classification loses its sensitivity but gains its predictive value.

Keywords: Lupus; ACR; SLICC; EULAR; Sensitivity


  1. Bertsias George K., et al. “Diagnostic criteria for systemic lupus erythematosus: has the time come?”. Nature Reviews Rheumatology11 (2013): 687-694.
  2. Larosa Maddalena., et al. “Advances in the diagnosis and classification of systemic lupus erythematosus.” Expert Review of Clinical Immunology12 (2016): 1309-1320.
  3. Costedoat-Chalumeau N., et al. “Les nouveaux critères de classification du lupus systémique (SLICC)”. Revue de Médecine Interne (2014).
  4. Martin Ringer. “EULAR/ACR classification criteria for SLE”. Seminars in Arthritis and Rheumatism3 (2019): 14-17.
  5. Petri Michelle., et al. “Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus”. Arthritis and Rheumatism8 (2012): 2677-2686.
  6. Mosca M., et al. “European League Against Rheumatism recommendations for monitoring patients with systemic lupus erythematosus in clinical practice and in observational studies”. Annals of the Rheumatic Diseases7 (2010): 1269-1274.
  7. Y Mohammed., et al. “Nouveaux critères de classification du lupus systémique : quel apport en pratique?”. La Revue de Médecine Interne2 (2016): A78-A79.
  8. Ezgi D., et al. “The Performances of the ACR 1997, SLICC 2012, and EULAR/ACR 2019 Classification Criteria in Pediatric Systemic Lupus Erythematosus”. The Journal of Rheumatology6 (2021): 907-914.
  9. Reem A., et al. “Evaluating the performance of ACR, SLICC and EULAR/ACR classification criteria in childhood onset systemic lupus erythematosus”. Pediatric Rheumatology Online Journal141 (2021).


Citation: Nada Jnyah., et al. “ACR, SLICC, EULAR: Which Sensitivities in the Diagnosis of Lupus?”.Acta Scientific Medical Sciences 6.4 (2022): 69-72.


Copyright: © 2022 Nada Jnyah., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.403

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 10, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US