Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Editorial Volume 6 Issue 4

Plastics and Our Lysosome: The Modulator of Hepatic Health

Eshika Bindal, Kiran Gill, Parul Garg, Rajasri Bhattacharyya and Dibyajyoti Banerjee*

Experimental Medicine and Biotechnology Department, Postgraduate Institute of Medical Education and Research, India

*Corresponding Author: Dibyajyoti Banerjee, Experimental Medicine and Biotechnology Department, Postgraduate Institute of Medical Education and Research, India.

Received: February 23, 2022; Published: March 01, 2022

Alcohol has been known for a long to cause a spectrum of liver diseases [1]. Nevertheless, in the absence of alcoholism, a similar illness is reported. It is known as nonalcoholic fatty liver disease (NAFLD). NAFLD is increasing at a tremendous rate [2]. Scientists are showing that plastic leaks out can cause such disease [3]. It is seen that Bisphenol A and Bisphenol F (the two plastic leak outs) cause lysosomal dysfunction [4-6]. Lysosomal dysfunction can cause lipid accumulation in the cell as it regulates cellular lipid catabolism [7]. Therefore, Bisphenol A and Bisphenol F induced lysosomal dysfunction can result in lipid accumulation in the liver. So, Bisphenol A and Bisphenol F exposure can get lipid accumulation in the liver, which can cause NFALD. This can happen in the absence of alcoholism [4,5].

References

  1. Yokoyama Y., et al. “Analysis of factors affecting birthweight, birth length and head circumference: study of Japanese triplets”. Twin Research and Human Genetics6 (2005): 657-663.
  1. Osna NA., et al. “Alcoholic Liver Disease: Pathogenesis and Current Management”. Alcohol Research 38 (2017): 147-161.
  2. Younossi Z., et al. “Global Perspectives on Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis”. Hepatology 69 (2019): 2672-2682.
  3. Dallio M., et al. “Chemical Effect of Bisphenol A on Non-Alcoholic Fatty Liver Disease”. International Journal of Environmental Research and Public Health 16 (2019): 3134.
  4. Dallio M., et al. “Chemical Effect of Bisphenol A on Non-Alcoholic Fatty Liver Disease”. International Journal of Environmental Research and Public Health 16 (2019): 3134.
  5. Wang J., et al. “Bisphenol F induces nonalcoholic fatty liver disease-like changes: Involvement of lysosome disorder in lipid droplet deposition”. Environmental Pollution 271 (2021): 116304.
  6. Lv Q., et al. “Bisphenol A promotes hepatic lipid deposition involving Kupffer cells M1 polarization in male mice”. Journal of Endocrinology 234 (2017): 143-154.
  7. Larsen LE., et al. “Defective Lipid Droplet–Lysosome Interaction Causes Fatty Liver Disease as Evidenced by Human Mutations in TMEM199 and CCDC115”. Cellular and Molecular Gastroenterology and Hepatology 13 (2022): 583-597.
  8. Europe PMC n.d (2022).
  9. Le HH., et al. “Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons”. Toxicology Letters 176 (2008): 149-156.
  10. Serra H., et al. “Evidence for Bisphenol B Endocrine Properties: Scientific and Regulatory Perspectives”. Environmental Health Perspectives 127 (2019): 106001.
  11. Padberg F., et al. “Minor structural modifications of bisphenol A strongly affect physiological responses of HepG2 cells”. Archives of Toxicology 93 (2019): 1529-1541.

Citation

Citation: Dibyajyoti Banerjee. “Plastics and Our Lysosome: The Modulator of Hepatic Health”.Acta Scientific Medical Sciences 6.4 (2022): 01-02.

Copyright

Copyright: © 2022 Dibyajyoti Banerjee. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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