Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Editorial Volume 6 Issue 4

Plastics and Our Lysosome: The Modulator of Hepatic Health

Eshika Bindal, Kiran Gill, Parul Garg, Rajasri Bhattacharyya and Dibyajyoti Banerjee*

Experimental Medicine and Biotechnology Department, Postgraduate Institute of Medical Education and Research, India

*Corresponding Author: Dibyajyoti Banerjee, Experimental Medicine and Biotechnology Department, Postgraduate Institute of Medical Education and Research, India.

Received: February 23, 2022; Published: March 01, 2022

Alcohol has been known for a long to cause a spectrum of liver diseases [1]. Nevertheless, in the absence of alcoholism, a similar illness is reported. It is known as nonalcoholic fatty liver disease (NAFLD). NAFLD is increasing at a tremendous rate [2]. Scientists are showing that plastic leaks out can cause such disease [3]. It is seen that Bisphenol A and Bisphenol F (the two plastic leak outs) cause lysosomal dysfunction [4-6]. Lysosomal dysfunction can cause lipid accumulation in the cell as it regulates cellular lipid catabolism [7]. Therefore, Bisphenol A and Bisphenol F induced lysosomal dysfunction can result in lipid accumulation in the liver. So, Bisphenol A and Bisphenol F exposure can get lipid accumulation in the liver, which can cause NFALD. This can happen in the absence of alcoholism [4,5].

References

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  5. Wang J., et al. “Bisphenol F induces nonalcoholic fatty liver disease-like changes: Involvement of lysosome disorder in lipid droplet deposition”. Environmental Pollution 271 (2021): 116304.
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  7. Larsen LE., et al. “Defective Lipid Droplet–Lysosome Interaction Causes Fatty Liver Disease as Evidenced by Human Mutations in TMEM199 and CCDC115”. Cellular and Molecular Gastroenterology and Hepatology 13 (2022): 583-597.
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Citation

Citation: Dibyajyoti Banerjee. “Plastics and Our Lysosome: The Modulator of Hepatic Health”.Acta Scientific Medical Sciences 6.4 (2022): 01-02.

Copyright

Copyright: © 2022 Dibyajyoti Banerjee. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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