Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Research Article Volume 6 Issue 3

Status of Infectious Urolithiasis and Multi-resistant Bacteria Extended Spectrum β-lactamase in Algeria

Berrahal M*

Department of Medical - Microbiology, University 01 Algeria, Kouba, Algeria

*Corresponding Author: Berrahal M, Department of Medical - Microbiology, University 01 Algeria, Kouba, Algeria.

Received: January 07, 2022; Published: February 16, 2022


Introduction: We wanted to take stock of the new microbio-epidemiological trend of mixed urolithiasis infected or colonized by multi-resistant germs including multi-resistant enterobacteria bacteria extended spectrum β-lactamase and others.

Materials and Methods: Assess the impact of the microbiological study of the microbiological study (phenotypic and molecular) of pyelic urine and/or stone compared to standard urineculture (ECBU).

Results: 114 (03%) had an infected (or colonized) stone. Preoperative ECBU was 90% negative compared at the culture of urine pyelique and stone with 22% Proteus mirabilis, 15% Staphylococcus aureus, 11% K. pneumoniae and others emerging species. Antibiotic resistance detected in the stone and pyelic urine analysis: 60% of E. coli and 40% of K. pneumoniae resistant to Cefazolin (CIIG) with 60% resistance to ciprofloxacin in E. coli and 20% in K. pneumoniae. we had five extended spectrum β-lactamase strain: tow Enterobacter cloacae complex (ECC) and three K. pneumoniae.

Conclusion: Mixed infectious urolithiasis can be a real public health problem because, pathogenic germs sometimes alarmist due to their resistance to antibiotics and their etiopathogens or virulences and can be life-threatening for patients with additional costs, especially hospital and social care.

Keywords: Microbio-epidemiological; Extended Spectrum Beta-lactamase; Stone Culture; Pyelic Urine; Antibiotic Resistance; Vital Prognosis


  1. Daudon M. “Epidemiology of urolithiasis”. Paris (France): Elsevier Masson (2018).
  2. Logan LK. “A Multi-Centered Case-Control Study of Factors associated with Klebsiella pneumoniae carbapenemase producing Enterobacteriaceae infections in children and young adult”. The Pediatric Infectious Disease Journal 5 (2019): 490-495.
  3. Noël N and Rieu P. “Urinary lithiasis of infection”. EMC-Urology 06-02 (2013): 18-104-C-10.
  4. Daudon M and Traxer O. “Urinary lithiasis”. Paris (France): Médecine-Sciences-Lavoisier (2012): 672.
  5. Nishant P. “Multidrug Resistant Bacteriuria Before Percutaneou Nephrolithotomy Predicts for Postoperative Infectious Complications”. Journal of Endourology 15 (2015).
  6. De Miguel-Elízaga I and Martínez-Ruiz A. “Kidney stones in a Mediterranean population from the south of Spain”. Clinical Chemistry and Laboratory Medicine 50 (2011): 545-548.
  7. Oteo J and Orden B. “CTX-M-15 producing urinary E. coli 025 b-ST131phylogroupe Bé has acquired resistance to Fosfomycin”. Journal of Antimicrobial Chemotherapy 64 (2009): 712-717.
  8. Barguigua A and El Otmani F. “Prevalence and genotypic analysis of plasmid-mediated β-lactamases among urinary Klebsiella pneumoniae isolates in Moroccan community”. Journal of Antibiotics 66 (2013): 11-16.
  9. Nedjai M. “Prevalence and characterization of extended spectrum β-lactamases in Klebsiella-Enterobacter-Serratia group bacteria, in Algeria”. Médecine et Maladies Infectieuses1 (2012): 20-22.
  10. Saïdani M. “Emergence of carbapenem-resistant OXA-48 carbapenemase-producing Enterobacteriaceae in Tunisia”. Journal of Medical Microbiology12 (2012).
  11. Belbel Z. “Evaluation de la résistance aux antibiotiques des souches deKlebsiella pneumoniae isolées dans les hôpitaux d’Annaba”. Microbiologieappliquée (2014).
  12. Titelman E. “Antimicrobial susceptibility to parenteral and oral agents in a largely polyclonal collection of CTXM14 and CTXM15 producing Escherichia coli and Klebsiella pneumoniae”. Journal Pathology of Microbiology and Immunology 12 (2011).
  13. Bonnet R. “A Novel CTX-M β-Lactamase (CTX-M-8) in Cefotaxime-Resistant Enterobacteriaceae Isolated in Brazil”. American Society of Microbiology7 (2000): 1936-1942.
  14. Biendo M. “Successive emergence of extended-spectrum β-Lactamase-producing and Carbapenemase-producing Enterobacter aerogenes Isolates in a University Hospital”. American Society of Microbiology3 (2008).
  15. Aggoune N. “Wide spread of OX-48 producing Enterobacteriacae in Algerian hospital à four years study”. Journal of Infection in Developing Countries 11 (2018).
  16. Machuca J. “Caractérisation d'une épidémie due à Klebsiella pneumoniae producteur de CTX-M-15 dépourvu du blaOXA-48gene appartenant au clone ST405 dans une unité néonatale du sud de l'Espagne”. Journal of Antimicrobial Chemotherapy 71 (2016): 2353.
  17. Yan D. “Biofilm-forming Klebsiella pneumoniae strains have greater likelihood of producing extended-spectrum beta-lactamases”. Journal of Hospital Infection 4 (2004): 369-371.
  18. Surgersa L. “Biofilm formation by ESBL-producing strains of Escherichia coli and Klebsiella pneumoniae”. International Journal of Medical Microbiology 309 (2019): 13-18.
  19. Messai Y and Iabadene H. “Prevalence and characterization of extended-spectrumβ-lactamases in Klebsiella pneumoniae in Algiers hospitals (Algeria)”. Pathologie Biologie5 (2008): 319-325.


Citation: Berrahal M. “Status of Infectious Urolithiasis and Multi-resistant Bacteria Extended Spectrum β-lactamase in Algeria". Acta Scientific Medical Sciences 6.3 (2022): 103-109.


Copyright: © 2022 Berrahal M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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