Siva Kaliyamoorthy1,2, Varadharajaperumal Radhakrishnan1, Mutharasu Arasu2 and Jawahar Ramasamy1*
1Associate Professor, Department of Pathology, Aarupadai Veedu Medical College and Hospital, Vinayaka Mission’s Research Foundation (Deemed to be university),
Kirumampakkam Puducherry, India
2Associate Professor, Department of Pathology, Sri Manakula Vinayagar Medical College and Hospital, Puducherrya
*Corresponding Author: Jawahar Ramasamy, Professor, Department of Pathology, Aarupadai Veedu Medical College and Hospital, Vinayaka Mission’s Research Foundation (Deemed to be university), Kirumampakkam Puducherry, India.
Received: November 01, 2021; Published: December 21, 2021
Endometrial hyperplasia is defined as an abnormal proliferation of the endometrium with increased gland to stroma ratio and abnormalities in epithelial cells linked to prolonged exposure to estrogen stimulation. Endometrial curettings and hysterectomy specimens diagnosed with Endometrial Hyperplasia cases diagnosed with histopathologically were subjected to Immunohistochemical examination for Estrogen and Progesterone receptor status using DAKO monoclonal Estrogen Receptor (ER) and Progesterone Receptor (PR) antibody kit. A semiquantitative scoring system (H score system) has employed and a composite score of grade of intensity and percentage of stained cells. Most of the cases received and taken up for study belonged to the Reproductive age group of 18-46. The commonest clinical diagnosis of these cases was Dysfunctional uterine bleeding. Simple hyperplasia without atypia (SH) was found to be the commonest histopathological diagnosis in patients with Dysfunctional uterine bleeding. H scores of ER and PR in the glandular epithelial cells of these cases was showed PR scores being higher than ER in cases of SH. With the advent of newer hormonal therapies which can prove beneficial in avoiding surgical management, knowing the status of estrogen and progesterone receptors in the hyperplastic endometrium can prove a better therapeutic option compared to hysterectomy. Hormonal therapy using progestins can be tried before surgical management in patients with endometrial hyperplasia because the receptor status is favorable.
Keywords: Endometrial Hyperplasia; Estrogen Receptor; Progesterone Receptor; Dysfunctional Uterine Bleeding
Citation: Jawahar Ramasamy., et al. “A Study on Histopathological Association of Endometrial Hyperplasia with Estrogen Receptor, Progesterone Receptor Status”.Acta Scientific Medical Sciences 6.1 (2022): 226-232.
Copyright: © 2022 Jawahar Ramasamy., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.