Ricardo Méndez¹, José González¹*, Pilar A Soledispa², Enrique Gómez³ and Max Monan⁴

¹Facultad De Educación En Ciencias Técnicas, Ucp "Enrique José Varona", La Habana, Cuba

*Corresponding Author: José González, Facultad De Educación En Ciencias Técnicas, Ucp "Enrique José Varona", La Habana, Cuba.

Received: October 18, 2021; Published: December 09, 2021

Abstract

Smilax domingensis Willd. (Smilacaceae), also known as raíz de China and zarzaparrilla de la Tierra (Cuba), is a tropical American climbing shrub. The rhizome is widely used in medicine in manifold pharmacological activities. An evaluation was realized to determine the oral acute toxicity from an ethanolic extract of rhizomes of this spice that grows in Cuba in 25 CD1 female rats using a dosage in 2000, 300, 50, 5 mg/kg. for 14 days, were evaluating the weight, feeding and the presence/absence of toxic symptoms, according to The Commission of European Communities (ECDO). Histopathological results in liver and kidneys revealed that at 2000 mg/Kg was observed necrosis, hyperplasia in Kupffer cells and glomerular hypertrophy. At 300, 50 and 5 mg/Kg were detected inflammation on hepatocytes by edema and dilatation on renal tubules. No mortality was produced at different dosage used in the experiments (2000, 300, 50 and 5 mg/Kg), however, histopathological analysis evidenced that on hepatic and renal tissues were causing alterations.

Keywords: Smilax Domingensis; Oral Acute Toxicity; Histopathological Analysis; Kupffer’s Cells; Glomerular Hypertrophy

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Citation

Citation: José González., et al. “Oral Acute Toxicity of Ethanolic Extract of Rhizomes from Smilax domingensis Willd. in Cuba". Acta Scientific Medical Sciences 6.1 (2022): 78-81.

Copyright

Copyright: © 2022 José González., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.