Acta Scientific Medical Sciences (ISSN: 2582-0931)

Case Report Volume 5 Issue 10

Three Cases with Artifacts Presented in the Form of Intensive Diffuse Accumulation in the Liver and Spleen After Application of 99mTcMDP

Luljeta Abdullahu1, Armend Jashari1, Ylli Kaçiu1 and Naser Gjonbalaj2

1Department of Nuclear Medicine, University Clinical Center of Kosovo “UCCK”, Prishtina
2Clinic of Radiology University Clinical Center of Kosovo “UCCK”, Prishtina

*Corresponding Author: Luljeta Abdullahu, Department of Nuclear Medicine, University Clinical Center of Kosovo “UCCK”, Prishtina.

Received: June 25, 2020 Published: September 25, 2021

Citation: Luljeta Abdullahu., et al. “Three Cases with Artifacts Presented in the Form of Intensive Diffuse Accumulation in the Liver and Spleen After Application of 99mTcMDP". Acta Scientific Microbiology 5.10 (2021): 167-171.


The literature refers to various cases of non osseous uptake of 99mTc-MDP , and various examples are presented about radio-bio distribution problems of osteotropic radiopharmaceuticals, which may be unpredicted or altered, for which it is not it is always possible to conclude that this radiopharmaceutical (this agen t) can be absorbed in areas far from active bone formations where calcification is not present.

Purpose: We report 3 cases with intensive diffuse uptake of 99mTc-MDP in the liver and spleen in patients with primary breast tumor, lung tumor and a suspected case of osteomyelitis, brought to our department, with the aim of detecting metastases in the skeleton respectively diagnosing the primary process to an adolescent's on left ankle. The aim is to interpret / refer to and discuss these cases with detected artifacts that exhibit difficulties in identifying soft tissue etiologies, organized according to the uptake mechanisms of 99mTc-MDP.

Discussion: One of the impurities that can sometimes be observed in the eluent samples from the generators is Aluminium, in addition to the reduced 99mTc hydrolysis process, also due to the excessive amount of Al3 which would cause the particles to form as a digestion "colloid" which, if injected, will be localized in the liver and spleen.

Impression: In my experience almost 20 years ago, this is the first time I've had the chance to see such an artifact, such as intensive diffuse uptake of liver and spleen, along with the 99mTc-MDP accumulation on skeleton, until in the literature I had the opportunity to see and read about the various causes of this phenomenon, such as these presented cases, we would like to share this experience with you with presented facts. How much other artifacts like focal accumulation in the liver, lung, amyloidosis of the heart and unusual or common accumulation in soft tissues and other organs outside bone tissue have been the most different.

Keywords: 99mTc MDP; 99mTc Generator; Colloid Particles; Liver; Spleen; Skeleton; Siemens-E-Cam Dual Head Gamma Camera


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Copyright: © 2021 Lakshmi Jyothi Tadi., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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