Moving Boundary Model to Estimate Diffusion Coefficient and Viscosity of Dextran Coated Magnetic Iron-Oxide Using Capillary Electrophoresis
Tajudeen Adebileje1, Rahimeh Rasouli2, Amir Amani2 and Reza Faridi-Majidi2*
1Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences-International Campus, Tehran, Iran
2Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
*Corresponding Author: Reza Faridi-Majidi, Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Received:June 07, 2021; Published: July 26, 2021
Capillary electrophoresis serves as a suitable analytical method to characterize the properties of samples through the application of pressure and voltage within a capillary tube. We present a categorized interface boundary problem of liquids to estimate the diffusion coefficient (DC) and viscosity of dextran- coated magnetic iron oxide (Dextran-MIOS) confined in formic acid solution (FAS). We considered an interface, with a dimension greater than zero, between samples filled into the capillary tube followed by either FAS or water flow at constant pressure (104 pa). We fitted the time point corresponding to interface minimum frequency, maximum frequency, Inflection frequency, and also the apparent volume of liquid between the frequencies into viscosity and moving boundary diffusion models. We used the factorial design of experiments for the design/evaluation of sample constituents by considering the concentration of FA (CFA) and volume fraction of Dextran-MIOS (VFDextran-MIOS) on DC and viscosity. We observed a symmetry behavior of CFA and VFDextran-MIOS in samples on the DC of Dextran-MIOS during FAS flow, while there is a loss in symmetry during water flow. We observed a symmetry behavior of only VFDextran-MIOS in samples on the viscosity of Dextran-MIOS during FAS flow, while there is a change in symmetry during water flow.
Keywords: Dextran Coated Magnetic Iron-oxide; Diffusion Coefficient; Viscosity; Formic Acid Solution; and Fractional Factorial Design
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