Bharat Lal¹ and Manoj Gadewar²*

¹Department of Pharmaceutics, K.R. Mangalam University, Haryana, India
²Department of Pharmacology, K.R. Mangalam University, Haryana, India

*Corresponding Author: Manoj Gadewar, Department of Pharmacology, K.R. Mangalam University, Haryana, India.

Received: June 18, 2021; Published: July 22, 2021

Abstract

A rapid, specific RPHPLC technique has been developed for simultaneous resolve of risperidone and olanzapine. Drugs were subjected to stress conditions such as acidic, alkaline and oxidative hydrolysis. Chromatographic separation of these pure drugs was carried with a 50:50 (v:v) mixture of acetonitrile and Potassium Di Hydrogen Phosphate and 40:60 (v:v) mixture of acetonitrile and Potassium Di Hydrogen Phosphate Buffer as mobile stage. The current rate was 1.0 mL min-1 and the analysis was monitored at 235 nm by UV detection.

Keywords: Risperidone; Olanzapine; RP-HPLC; Acetonitrile; Potassium

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Citation

Citation: Bharat Lal and Manoj Gadewar. “Simultaneous Estimation of Antipsychotic Drugs (Risperidone and Olanzapine) by RPHPLC”.Acta Scientific Medical Sciences 5.8 (2021): 128-135.

Copyright

Copyright: © 2021 Bharat Lal and Manoj Gadewar. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.