Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Mini Review Volume 5 Issue 8

Nanopulse Stimulation as a Possible Immunotherapy

Stephen J Beebe*

Frank Reidy Research Center for Bioelectrics, Old Dominion University, Virginia, USA

*Corresponding Author: Stephen J Beebe, Frank Reidy Research Center for Bioelectrics, Old Dominion University, Virginia, USA.

Received: May 06, 2021; Published: July 08, 2021


  Nanopulse stimulation (NPS) presents a novel approach for cancer treatment. It applies high electric field pulses with ultrashort durations and fast rise-fall times, affecting the plasma membrane and intracellular structures and functions, inducing regulated cell death mechanisms that are immunogenic, eliminating tumors and their immunosuppressive tumor microenvironment, and activating innate and adaptive immune mechanisms. This results in tumor ablation and in situ vaccination against rat liver and mouse breast cancer. Here I provide a general overview of this technology and some finer points of the pulsed power technology.

Keywords: Pulsed Power; Tumor Ablation; In Situ Vaccination; Immunosuppression; Innate Immunity; Adaptive Immunity


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Citation: Stephen J Beebe. “Nanopulse Stimulation as a Possible Immunotherapy”.Acta Scientific Medical Sciences 5.8 (2021): 10-14.


Copyright: © 2021 Stephen J Beebe. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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