Cutaneous Manifestation and Vasculitis of COVID-19 in Dermatology
Department of Radiology, Nihon University School of Medicine, Tokyo, Japan
*Corresponding Author: Kazumi Fujioka, Department of Radiology, Nihon University School of Medicine, Tokyo, Japan.
Received: April 05, 2021; Published: May 06, 2021
The emerging coronavirus disease 2019 (COVID-19) by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide outbreak and still has spread relentlessly and recrudescence due to the new mutants begin to occur. The respiratory failure from acute respiratory distress syndrome (ARDS) presents the major cause of mortality and multi-organ failure represents other causes of mortality in patients with COVID-19. It has been revealed that SARS-CoV-2 infection induces the protean clinical manifestations from head to toe, affecting the multiple organ systems including the lungs, heart, brain, kidney, skin, and vasculature. In this article, the cutaneous features and vasculitis in COVID-19 in dermatological field were reviewed. Based on the evidences, it is suggested that the common cutaneous manifestation caused by SARS-CoV-2 infection is chilblains. The direct-induced skin damage and/or a systemic inflammatory reaction by the indirect injury may be considered as the pathophysiological mechanisms in vasculitis of COVID-19. The author suggests that COVID-19 represents an endothelial disease and may be a systemic disease or a multiorgan disease based on the vasculitis in the microvasculature.
Keywords: Vasculitis; Chilblains; Endothelial Disease; SARS-CoV-2; COVID-19
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