Abstract

  The present study aimed to prove the protective role of flaxseed oil (FSO) against lead (Pb) in male rats by measuring the enzyme activities as well as the concentration of some parameters and the histological changes in liver tissues. Forty adult male rats weighing 150-200 g were divided into four groups, control group received distilled water, group two orally administered 60 mg/kg b.w. lead acetate by using the stomach tube day after day, group three orally administered 600 mg/kg b.w. FSO using stomach tube day after day, group four orally administered 600 mg/kg b.w. FSO then 60 mg/kg b.w. lead acetate day after day for four weeks. The results showed an increase in the activity of ALT, AST, ALP and GGT enzymes in group administered lead acetate compared with control group, and convergence in results was observed in the group administered FSO compared with control group. While, in the group administered both FSO and lead acetate, the levels of these enzymes decreased compared to Group II, which was administered lead acetate only. Rats administered lead acetate showed an increase in the values of TBIL, TP, GLU, and ALB. It was observed that there was a convergence in all their values in the group administered FSO compared with control group. While these values were decreased in the group administered both FSO and lead acetate compared to Group II administered lead acetate only. The results of the histological examination, after administration of lead acetate, changes were appeared as swollen, necrotic and apoptotic hepatocytes. Also, many of the portal areas were completely masked by accumulation of inflammatory mononuclear cells and bile ducts were difficult to be seen. Administration of flaxseed oil before lead acetate in the 3rd group showed a significant enhance in the histopathology of the liver cells. The results showed an effect of lead on biochemical measurements, as well as pathological effects on liver tissues in rats. On the contrary, the results showed the protective role of flaxseed oil in maintaining the biochemical parameters and histological tests with their levels and status in the control group. These results confirmed the effective role of FSO against lead and by raising the efficiency of the body to protect or treat it against toxins that affect the important organ of the body the liver.

Keywords: Flaxseed Oil; Lead Acetate; Physiology; Histology; Liver; Rats

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Citation

Citation: Aljedaani HM., et al. “Role of Flaxseed Oil Against Lead Toxicity in Liver of Male Rats”.Acta Scientific Medical Sciences 5.1 (2021): 84-96.

Copyright

Copyright: © 2021 Aljedaani HM., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.