Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Case Report Volume 5 Issue 1

Metaplastic Breast Cancer - A Difficult Diagnosis Even on Histology

Ratish Karn1*, Abhijeet Kumar2, Suresh Prasad Shah3 and Rakesh Gupta4

1Senior Resident, Department of Surgery, BPKIHS, Dharan, Nepal
2Assistant professor, Department of surgery, BPKIHS, Dharan, Nepal
3Additional Professor, Department of Surgery, BPKIHS, Dharan, Nepal
4Professor, Department of surgery, BPKIHS, Dharan, Nepal

*Corresponding Author: Ratish Karn, Senior Resident, Department of Surgery, BPKIHS, Dharan, Nepal.

Received: November 10, 2020; Published: December 22, 2020



  Metaplastic (carcinosarcomas) carcinomas of breast are a heterogenous group of malignant tumours in which part or all of the carcinomatous epithelium is transforrmed into a nonglandular growth process. We report herein a 71-year-old female who came to us with progressive painless lump in her right breast behind the nipple-areolar complex for 5 months. She had undergone FNAC(Fine Needle Aspiration Cytology) as well as Core biopsy multiple times; and each time it was reported as inflammatory mass only. Core wide local excision followed by mammoplasty was performed and histopathology reported it as metaplastic carcinoma with mesenchymal differentiation.
Though there are already few cases well described in Literature about metaplastic cancer, this paper describes the challenge of FNAC or Core biopsy to sub-classify breast mass.

Keywords: Metaplastic Carcinoma; Mesenchymal Differentiation; Breast Lump



  1. Barnes PJ., et al. “Metaplastic breast arcinoma:clinical-pathologic characteristics and HER2/nue expression”. Breast Cancer Research and Treatment 91 (2005): 173-178.
  2. World Health Organization (WHO): WHO Classification of Tumors of the Breast, ed 4. Geneva, WHO (2012).
  3. El Zein D., et al. “Metaplastic Carcinoma of the Breast Is More Aggressive Than Triple-negative Breast Cancer: A Study From a Single Institution and Review of Literature”. Clinical Breast Cancer5 (2017): 382-391.
  4. Salemis NS. “Metaplastic carcinoma of the breast with mesenchymal differentiation (carcinosarcoma). A unique presentation of an aggressive malignancy and literature review”. Breast Disease3 (2018): 169-175.
  5. Patterson SK., et al. “Metaplastic carcinoma of the breast: mammographic appearance with pathologic correlation”. AJR American Journal of Roentgenology 169 (1997): 709-712.
  6. Wagotz ES., et al. “Metaplastic carcinoma of the breast II. Spindle cell carcinoma”. Human Pathology 20 (1989): 732-740.
  7. Soler Monsó MT., et al. “Metaplastic carcinoma of the breast with chondroid differentiation (matrix-producing carcinoma): study of the diagnostic cost-effectiveness of fine-needle aspiration biopsy and needle core biopsy”. Acta Cytology1 (2014): 9-14.
  8. Rayson D., et al. “Metaplastic breast cancer: prognosis and response to systemic therapy”. Annals of Oncology 10 (1999): 413-419.
  9. Kurian KM and Al-Natussi A. “Sarcomatoid/metaplastic carcinoma of the breast: a clinicopathological study of 12 cases”. Histopathology 40 (2002): 58-64.
  10. Goldhirsch A., et al. “Meeting Highlights: International Consensus Panel on the Treatment of Primary Breast Cancer”. Journal of Clinical Oncology 19 (2001): 3817-3827.


Citation: Ratish Karn. “Metaplastic Breast Cancer - A Difficult Diagnosis Even on Histology”. Acta Scientific Medical Sciences 5.1 (2021): 70-72.


Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.403

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is June 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US