Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Research Article Volume 4 Issue 11

Evaluation of Route of Administration (Via Portal Vein) for Assessing the Role of Stem Cell Therapy in Cirrhosis of Liver

Mamun Al Mahtab1, Ahmed Lutful Moben2, Md Abdur Rahim3, Md Ashraful Alam4, Faiz Ahmad Khondaker5, Sheikh Mohammad Noor-E-Alam1, Md Sakirul Islam Khan6, Md Zahurul Huq7, Musarrat Mahtab8 and Sheikh Mohammad Fazle Akbar9,10*

1Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
2Department of Medicine, Kurmitola General Hospital, Dhaka, Bangladesh
3Department of Hepatology, Abdul Malek Ukil Medical College, Noakhali, Bangladesh
4Department of Hepatology, Shaheed Tajuddin Ahmed Medical College, Gazipur, Bangladesh
5Department of Hepatology, Shaheed Suhrawardy Medical College, Dhaka, Bangladesh
6Department of Anatomy and Embryology, Ehime University Graduate School of Medicine, Ehime, Japan
7Department of Anesthesiology, National Institute of Cardiovascular Diseases, Dhaka, Bangladesh
8Department of Biochemistry and Biotechnology, North South University, Dhaka, Bangladesh
9Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan
10Researcher, Miyakawa Memorial Research Foundation, Tokyo, Japan

*Corresponding Author: Sheikh Mohammad Fazle Akbar, Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan.

Received: September 14, 2020; Published: October 12, 2020

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Abstract

Aims and Objectives: The safety and efficacy of stem cell administration via portal vein was assessed in patients with cirrhosis of liver (LC).

Materials and Methods: In order to increase the numbers of white blood cell, 20 patients with liver cirrhosis were administered with granulocyte colony-stimulating factor at a dose of 60 IU, daily for 3 to 4 days. Stem cells were isolated from these patients as CD34-positive cells and variable numbers of autologous stem cells were injected to LC patients for once. Various hematological and clinical parameters of these patients were evaluated at point 0 (before administration of stem cells) and 1 and 3 months after administrations.

Results: None of these 20 patients died within 3 months of observation period. Regarding safety issues, there was no notable adverse event including acute liver failure related to stem cell therapy in these patients. Stem cell therapy had a dominant effect on ascites in this cohort. Although 7 of 20 patients had ascites at the start of therapy, 2 of these patients became ascites free at the end of 3 months of follow up. On the other hand, 5 patients of LC who did not have ascites at base line developed ascites during therapy. Different biochemical parameters of these patients remain mostly unchanged and did not show any significant difference dur to stem cell therapy. However, serum albumin level was increased significantly after 1 and 3 months.

Conclusion: The safety of stem cell therapy via portal vein has been shown here. The efficacy of stem cell therapy via portal vein may not be notable. However, observed effects of this therapy on ascites reduction in some patients and on effect on serum albumin indicate that repeated administration of stem cell therapy may be needed for maintaining quality of life.

Keywords: Cirrhosis of Liver (LC); Stem Cell Therapy; Hepatic Parenchyma

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References

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Citation

Citation: Sheikh Mohammad Fazle Akbar.. et al. “Evaluation of Route of Administration (Via Portal Vein) for Assessing the Role of Stem Cell Therapy in Cirrhosis of Liver". Acta Scientific Medical Sciences 4.11 (2020): 27-31.




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