Khaled Mohammed Al-Qahtani1*, Ali Alhamdan1, Wael F Alblowi2, Mohammed Manei Al-Amri3 and Mohammed Hasan Almalki4
1Department of Internal Medicine, Resident of internal Medicine at King Saud Medical City, Saudi Arabia
2Department of Internal Medicine, Medical Consultant, Allergist and Clinical Immunologist at King Saud Medical City, Saudi Arabia
3Department of Internal Medicine, Consultant of internal Medicine and at King Saud Medical City, Saudi Arabia
4Department of Internal Medicine, Medical Consultant and toxicologist at King Saud Medical City, Saudi Arabia
*Corresponding Author: Khaled Mohammed Al-Qahtani, Department of Internal Medicine, Resident of internal Medicine at King Saud Medical City, Saudi Arabia.
Received: August 15, 2020; Published: August 31, 2020
The authors herein report a case of severe combined immunodeficiency (SCID) secondary to a rare genetic mutation of CARMIL2. Presented initially as a case of celiac disease then further investigated to reach the diagnosis of SCID secondary to CARMIL2. Furthermore, the patient has got infected by the recent pandemic COVID-19 and surprisingly passed through the infection asymptomatically. Consequently, discussion regarding of the association and pathophysiology of SCID and COVID-19 and how the underlying disease affected the results of the course of the disease. Interestingly, in our case the rationale of asymptomatic presentation of the disease is not clearly explained in the current literature whether its due to escape of the cytokine storm that the infection causes. Our hypothesis is that due to the severe immunodeficiency in our patient, it evidently helped her to avoid dysregulated immune responses to the virus and escape possible immunopathology status.
Keywords: Primary Immunodeficiency (PID); CARMIL2; COVID-19
Citation: Khaled Mohammed Al-Qahtani., et al. “Successful Handling of Covid-19 in a Young Patient with SCID due to CARMIL2 (RLTPR) Deficiency: Case Report and Review of Literature". Acta Scientific Medical Sciences 4.9 (2020): 133-136.
Copyright: © 2020 Khaled Mohammed Al-Qahtani., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.