Acta Scientific Medical Sciences (ISSN: 2582-0931)

Case Report Volume 4 Issue 9

Acral Myxoinflammatory Fibroblastic Sarcoma of the Foot: A Case Report

Khaled Khelil1*, Saber Saadi1, Abderrazek Rafrafi1, Rami Ben Arab1, Talel Znagui1, Nadia Boujelben2, Mounira Khezami1 and Lotfi Nouisri1

1Department of Orthopedics, The Military Hospital of Instruction of Tunis, Tunis, Tunisia
2Department of Anatomopathology, Institute Salah Azaiez Tunis, Tunisia

*Corresponding Author: Khaled Khelil, Department of Orthopedics, The Military Hospital of Instruction of Tunis, Tunis, Tunisia.

Received: June 28, 2020; Published: August 26, 2020



Myxoinflammatory fibroblastic sarcoma is a rare low grade malignant soft tissue tumor, mainly affecting middle-aged persons, and located in the distal extremities. The absence of clinical and radiological signs specific to this tumor makes it confused with many benign lesions and leads to inappropriate treatment. Though it is classified as a low grade tumor, it is reported to have an important infiltrative character responsible for a considerable rate of local recurrence. The therapeutic management of this tumor remains a subject of debate, there are no formal standard treatment protocols. In this presentation, we aimed to report the case of a patient with myxoinflammatory fibroblastic sarcoma of the foot treated successfully by surgery with adjuvant radiotherapy.

Keywords: Acral Myxoinflammatory Fibroblastic Sarcoma (AMIFS); Radiotherapy; Foot



  1. Meis-Kindblom JM., et al. “Acral myxoinflammatory fibroblastic sarcoma: a low-grade tumor of the hands and feet”. The American Journal of Surgical Pathology 22 (1998): 911.
  2. Montgomery EA., et al. “Inflammatory myxohyaline tumor of distal extremities with virocyte or Reed-Sternberg-like cells: a distinctive lesion with features simulating inflammatory conditions, Hodgkin’s disease, and various sarcomas”. Modern Pathology 11 (1998): 384.
  3. M Miettinen., et al. “Inflammatory myxohyaline tumor od distal extremities (acral myxoinflammatory fibroblastic sarcoma)”. In Tumors of the Soft Tissues, S. G. Silverberg, Edition (2014): 190-192.
  4. JM Meis., et al. “Myxoinflammtory fibroblastic sarcoma”. In WHO Classification of Tumours of Soft Tissue and Bone, C. D. M. Fletcher, J. A. Bridge, P. C. W. Hogendoorn, and F. Mertens, Editions (2013): 87-88.
  5. Chahdi H., et al. “Acral myxoinflammatory fibroblastic sarcoma”. Orthopaedics and Traumatology: Surgery and Research 96 (2010): 597-599.
  6. E Ieremia and K Thway. “Myxoinflammatory fibroblastic sarcoma: morphologic and genetic updates”. Archives of Pathology and Laboratory Medicine 138.10 (2014): 1406-1411.
  7. CR Antonescu., et al. “Consistent t (1;10) with rearrangements of TGFBR3 and MGEA5 in both myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor”. Genes, Chromosomes and Cancer 50.10 (2011): 757-764.
  8. A Mansoor., et al. “Myxoinflammatory fibroblastic sarcoma with complex supernumerary ring chromosomes composed of chromosome 3 segments”. Cancer Genetics and Cytogenetics 152.1 (2004): 61-65.
  9. AG Silver., et al. “Acral myxoinflammatory fibroblastic sarcoma: A case report and literature review”. Canadian Journal of Plastic Surgery 21.2 (2013): 92-94.
  10. Lang J E., et al. “Case reports: acral myxoinflammatory fibroblastic sarcoma: a report of five cases and literature review”. Clinical Orthopaedics and Related Research 445 (2006): 254-260.
  11. Lombardi R., et al. “A case of lung metastasis in myxoinflammatory fibroblastic sarcoma: analytical review of one hundred and thirty-eight cases”. International Orthopaedics 37 (2013): 2429-2436.
  12. Baldini EH., et al. “Long-term outcomes after function-sparing surgery without radiotherapy for soft tissue sarcoma of the extremities and trunk”. Journal of Clinical Oncology 17 (1999): 3252-3259.
  13. Tejwani A., et al. “Management of acral myxoinflammatory fibroblastic sarcoma”. Cancer 116 (2010): 5733-5739.
  14. Hassanein A., et al. “Acral myxoinflammatory fibroblastic sarcomas: Are they all low-grade neoplasms?” Journal of Cutaneous Pathology 35 (2008): 186-191.


Citation: Khaled Khelil., et al. “Acral Myxoinflammatory Fibroblastic Sarcoma of the Foot: A Case Report". Acta Scientific Medical Sciences 4.9 (2020): 97-101.


Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.403

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 30, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US