Acta Scientific Medical Sciences (ISSN: 2582-0931)

Case Report Volume 4 Issue 8

Madelung’s Disease and Upper Airway Involvement: A Case Report

Daniela Furno1, Giovanni Addolorato2, Gaetano Paludetti1 and Gabriella Cadoni1

1Department of Head and Neck Surgery, Catholic University of the Sacred Heart, Rome, Italy, Fondazione Policlinico Universitario Gemelli, IRCSS, Rome, Italy
2Department of Internal Medicine and Gastroenterology, Catholic University of Rome, Catholic University of the Sacred Heart, Rome, Italy, Fondazione Policlinico Universitario Gemelli, IRCSS, Rome, Italy

*Corresponding Author: Gabriella Cadoni, Department of Head and Neck Surgery, Catholic University of the Sacred Heart, Rome, Italy, Fondazione Policlinico Universitario Gemelli, IRCSS, Rome, Italy.

Received: July 01, 2020; Published: August 12, 2020



Madelung’s disease is a rare condition characterized by multiple and symmetrical deposits of adipose tissue concerning especially neck, shoulders, upper limbs and upper thorax. This lipomatous tissue could cause extrinsic compression or recurrent laryngeal nerve compression because of infiltration of fat [1,2].
In this case, we will describe a 66-year-old man affected by Madelung’s disease, with larynx-tracheal anatomical alteration, showed by CT scan and flexible laryngoscopy.

Keywords: Madelung’s Disease; Lipomatosis; Upper Airways; Larynx; Videorhinolaryngoscopy



  1. Borges A., et al. “Laryngeal involvement in multiple symmetric lipomatosis: the role of computed tomography in diagnosis”. American Journal of Otolaryngology 18 (1997): 127-130.
  2. Zhang XY., et al. “Madelung disease: manifestations of CT and MR imaging”. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 105 (2008): e57-e64.
  3. Keller SM., et al. “Benign symmetrical lipomatosis”. Southern Medical Journal 11 (1986): 1428-1429.
  4. Gemperli R., et al. “Tratamento cirúrgico da lipomatose simétrica múltipla: doença de Madelung”. Revista Paulista De Medicina 6 (1988): 313-316.
  5. , et al. “Multiple symmetric lipomatosis may be the consequence of defective noradrenergic modulation of proliferation and differentiation of brown fat cells”. Journal of Pathology 198 (2002): 378-387.
  6. Brea-García B., et al. “Madelung’s disease: comorbidities, fatty mass distribution, and response to treatment of 22 patients”. Aesthetic Plastic Surgery 37 (2013): 409-416.
  7. Hirose A., et al. “Benign symmetric lipomatosis associated with alcoholism”. In- tern Medicine 45 (2006): 1001-1005.
  8. Mevio E., et al. “Multiple symmetric lipomatosis: a review of 3 cases”. Case Report on Otolaryngology (2012): 910526.
  9. Amicucci G., et al. “Madelung’s disease. Clinical case and review of the literature [Article in Italian]”. Minerva Chirurgica 53 (1998): 655-657.
  10. Ahuja AT., et al. “Madelung disease: distribution of cervical fat and preoperative findings at sonography, MR, and CT”. AJNR American Journal of Neuroradiology 19 (1998): 707-710.
  11. Plotnicov NA., et al. “Madelung’s disease (benign symmetric lipomatosis)”. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology3 (2018): e2018030.
  12. Pinto CI., et al. “Madelung’s disease: revision of 59 surgical cases”. Aesthetic Plastic Surgery 41 (2017): 359-368.
  13. R Herrnans., et al. Benign symmetric lipomatosis of the neck or Madelung- Launois-Bensaude syndrome, also known as Madelung's neck: CT findings in two cases (1994).
  14. V Pinto., et al. “A case of severe obstructive sleep apnoea in Madelung’s disease treated by lateral pharyngoplasty”. The Journal of Laryngology and Otology (2017).
  15. Oliven A., et al. “Mechanical parameters determining pharyngeal collapsibility in patients with sleep apnea”. Journal of Applied Physiology 109 (2010): 1037-1044.


Citation: Gabriella Cadoni., et al. “Madelung’s Disease and Upper Airway Involvement: A Case Report".Acta Scientific Medical Sciences 4.9 (2020): 08-11.


Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.403

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 10, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US