Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Research Article Volume 4 Issue 8

Does Sneezing Play a Role in Multiple Sclerosis?

Homayoun Roshanisefat1,2*

1Department of Neurology, Slagelse Hospital, 4200 Slagelse-DK, Sweden
2Division of Rehabilitation Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd University Hospital, 182 88 Stockholm-SE, Sweden

*Corresponding Author: Homayoun Roshanisefat, Department of Neurology, Slagelse Hospital, 4200 Slagelse-DK, Sweden and Division of Rehabilitation Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd University Hospital, 182 88 Stockholm-SE, Sweden. E-mail: homr@regionsjaelland.dk

Received: April 20, 2020; Published: July 28, 2020

×

Abstract

Objectives: The modern era of multiple sclerosis (MS) biomarkers has been ongoing for many years, with the periodical approval and renewing of MS criteria we are still facing many challenges. The new revision was recently approved, a few years after McDonald's Criteria, it was also followed by a promise to find new landmarks for the establishment of an MS diagnosis and its courses. An innate immunological clinical sign - which can better connect the suspected etiology and the disease is of major interest.

Data Sources: A literature search was performed using medical and health science search engines to find publications from January 1940 to December 2019.

Data Extraction: Data were extracted if any of the following keywords were mentioned in combination: sneezing, MS, stroke, biomarker, the nasal cavity. The search was expanded to the medical conditions included in this study.

Data Synthesis: Sneezing is a very clear sign and health reaction which has never been studied in MS and may potentially have a clinical impact. The sneeze function can, through other diseases and life events, teach us its importance and common understanding with MS. This review will focus on the sneeze in different medical conditions and use these comorbidities as a proxy to understand inflammation and their association with MS.

Conclusion: Sneezing is one of the common health reactions against pathogens, allergens, temperature changes, lightning, and cerebral injuries. This study has found a sign that sneezing has an untold role in MS and comorbidities such as a stroke. Measuring sneezes has the potential of becoming a clinical biomarker in MS.

Keywords: Sneezing; MS; Stroke; Biomarker; Nasal Cavity

×

References

  1. Filippi M., et al. “MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines”. Lancet Neurology3 (2016): 292-303.
  2. Giang HTN., et al. “The first Vietnamese case of COVID-19 acquired from China”. The Lancet Infectious Diseases 4 (2020): 408-409.
  3. Bourouiba L. “Turbulent Gas Clouds and Respiratory Pathogen Emissions: Potential Implications for Reducing Transmission of COVID-19”. JAMA (2020).
  4. Seijo-Martínez, M., et al. “Sneeze related area in the medulla: localisation of the human sneezing centre?” Journal of Neurology, Neurosurgery, and Psychiatry 4 (2006): 559-561.
  5. Nishino T. “Physiological and pathophysiological implications of upper airway reflexes in humans”. Japanese Journal of Physiology 1 (2000): 3-14.
  6. Watelet JB., et al. “Tissue remodelling in upper airways: where is the link with lower airway remodelling?” Allergy11 (2006): 1249-1258.
  7. Songu M and C Cingi. “Sneeze reflex: facts and fiction”. Therapeutic Advances in Respiratory Disease 3 (2009): 131-141.
  8. Yildiz E., et al. “Volume of the Cisternal Portion of the Trigeminal Nerve: A Study With 3.0-Tesla Constructive-Interference-in-Steady-State Imaging of Healthy Subjects”. Journal of Neurological Sciences1 (2015).
  9. Kress B., et al. “MRI volumetry for the preoperative diagnosis of trigeminal neuralgia”. European Radiology 7 (2005): 1344-1348.
  10. Kanchandani R and JG Howe. “Lhermitte's sign in multiple sclerosis: a clinical survey and review of the literature”. Journal of Neurology, Neurosurgery, and Psychiatry4 (1982): 308-312.
  11. Khan M., et al. “Trigeminal neuralgia, glossopharyngeal neuralgia, and myofascial pain dysfunction syndrome: an update”. Pain Research and Management (2017).
  12. Hughes AM., et al. “Early-life hygiene-related factors affect risk of central nervous system demyelination and asthma differentially”. Clinical and Experimental Immunology3 (2013): 466-474.
  13. Joffres MR., et al. “Environmental sensitivities: prevalence of major symptoms in a referral center: the Nova Scotia Environmental Sensitivities Research Center Study”. Environmental Health Perspectives2 (2001): 161-165.
  14. Harris RY. “Method for treating multiple sclerosis”. Google Patents (1997).
  15. Itoh K., et al. “Multifocal relapsing-remitting myelitis in a patient with atopic dermatitis: Multiple sclerosis or atopic myelitis?” Internal Medicine6 (2002): 495-497.
  16. Sahraian MA., et al. “Respiratory tract rather than cutaneous atopic allergy inversely associate with multiple sclerosis: A case–control study”. Clinical Neurology and Neurosurgery10 (2013): 2099-2102.
  17. Manouchehrinia A., et al. “Multiple sclerosis course and clinical outcomes in patients with comorbid asthma: a survey study”. BMJ open5 (2015): e007806.
  18. Nenov D., et al. “Treatment of Wegener's granulomatosis using plasmapheresis”. Vutr Boles6 (1983): 58-61.
  19. Masi AT., et al. “The American College of Rheumatology 1990 criteria for the classification of Churg‐Strauss syndrome (allergic granulomatosis and angiitis)”. Arthritis and Rheumatism8 (1990): 1094-1100.
  20. Degirmenci PB., et al. “Allergic Rhinitis and its Relationship with Autoimmune Thyroid Diseases”. American Journal of Rhinology and Allergy4 (2015): 257-261.
  21. López-Chiriboga AS., et al. “Paroxysmal sneezing in NMOSD: Further evidence of the localization of the human sneeze center”. Neurology-Neuroimmunology Neuroinflammation1 (2017): e303.
  22. Russi AE and MA Brown. “The meninges: new therapeutic targets for multiple sclerosis”. Translational Research2 (2015): 255-269.
  23. Hashimoto Y and A Futamura. “Prevalence of Allergic Rhinitis Is Lower in Subjects with Higher Levels of Fasting Plasma Glucose”. Diabetes Care11 (2010): e143-e143.
  24. Roshanisefat H., et al. “Multiple sclerosis clinical course and cardiovascular disease risk - Swedish cohort study”. European Journal of Neurology11 (2014): 1353-e88.
  25. Mathis S., et al. “Paroxysmal Sneezing at the Onset of Syncopes and Transient Ischemic Attack Revealing a Papillary Cardiac Fibroelastoma %”. Journal of Case Reports in Neurological Medicine (2014): 3.
  26. Bernat JL and L Suranyi. “Loss of ability to sneeze in lateral medullary syndrome”. Neurology4 (2000): 604-604.
  27. LeVine SM. “Is There an Increased Risk for Ischemic Stroke in Patients with Multiple Sclerosis, and If So, Should Preventive Treatment Be Considered?” Frontiers in neurology 7 (2017): 128-128.
  28. Vanaie M., et al. “The Effect of Sneezing on the Reduction of Infarct Volume and the Improvement of Neurological Deficits in Male Rats”. Advanced Biomedical Research 7 (2018): 142.
  29. Tan CL and ZA Knight. “Regulation of body temperature by the nervous system”. Neuron1 (2018): 31-48.
  30. Guthrie TC and DA Nelson. “Influence of temperature changes on multiple sclerosis: critical review of mechanisms and research potential”. Journal of the Neurological Sciences1 (1995): 1-8.
  31. Bamford CR., et al. “Seasonal variation of multiple sclerosis exacerbations in Arizona”. 33.6 (1983): 697-697.
  32. van Oosterhout., et al. “Migraine After Sneezing: Pathophysiological Considerations, Focused on the Difference With Coughing”. Headache: The Journal of Head and Face Pain7 (2013): 1147-1151.
  33. Martin VT., et al. “Chronic rhinitis and its association with headache frequency and disability in persons with migraine: results of the American Migraine Prevalence and Prevention (AMPP) Study”. Cephalalgia 5 (2014): 336-348.
  34. Goadsby PJ. “Pathophysiology of migraine”. Annals of Indian Academy of Neurology 15 (2012): S15-S22.
  35. Sprenger T and PJ Goadsby. “What has functional neuroimaging done for primary headache ... and for the clinical neurologist?” Journal of Clinical Neuroscience5 (2010): 547-553.
  36. Kister I., et al. “Migraine is comorbid with multiple sclerosis and associated with a more symptomatic MS course”. Journal of Headache Pain5 (2010): 417-425.
  37. Putzki N., et al. “Prevalence of migraine, tension-type headache and trigeminal neuralgia in multiple sclerosis”. European Journal of Neurology2 (2009): 262-267.
  38. Ader R., et al. “Psychoneuroimmunology: interactions between the nervous system and the immune system”. The Lancet 8942 (1995): 99-103.
  39. Melchiotti R., et al. “Genetic analysis of an allergic rhinitis cohort reveals an intercellular epistasis between FAM134B and CD39”. BMC Medical Genetics1 (2014): 73.
  40. Al-Shagahin HM., et al. “Vitamin D Status among Jordanian Patients with Allergic Rhinitis”.
  41. Sotirchos ES., et al. “Safety and immunologic effects of high- vs low-dose cholecalciferol in multiple sclerosis”. Neurology 4 (2016): 382-390.
  42. Dai YY., et al. “Stem cells from human exfoliated deciduous teeth correct the immune imbalance of allergic rhinitis via Treg cells in vivo and in vitro”. Stem Cell Research and Therapy1 (2019): 39.
  43. Uccelli A., et al. “MEsenchymal StEm cells for Multiple Sclerosis (MESEMS): a randomized, double blind, cross-over phase I/II clinical trial with autologous mesenchymal stem cells for the therapy of multiple sclerosis”. Trials 1 (2019): 263.
  44. Greiwe J and JA Bernstein. “Nonallergic Rhinitis: Diagnosis”. Immunology and Allergy Clinics of North America 2 (2016): 289-303.
  45. Karimi P., et al. “The relation of multiple sclerosis with allergy and atopy: a case control study”. Iranian Journal of Allergy, Asthma and Immunology 2 (2013): 182-9.
  46. Monteiro L., et al. “Association between allergies and multiple sclerosis: a systematic review and meta-analysis”. Acta Neurologica Scandinavica 1 (2011): 1-7.
  47. Jones R., et al. “The incidence of sinusitis in patients with multiple sclerosis”. Rhinology 35 (1997): 118-119.
  48. Schaefer SD. “Rhinology and sinus disease: a problem-oriented approach”. CV Mosby (1998).
  49. Bell GW., et al. “Maxillary sinus disease: diagnosis and treatment”. BDJ 210 (2011): 113.
  50. Asthma Society of Canada, Upper Respiratory Tract Infection Comparison Chart. Ah-choo! Is it a Cold, Hay Fever, Sinusitis or the Flu? (2017): 1.
  51. Martyn C and I Colquhoun. “Radiological evidence of sinus infection in patients with multiple sclerosis”. Journal of Neurology, Neurosurgery and Psychiatry 10 (1991): 925-926.
  52. Rothstein J., et al. “Relationship of optic neuritis to disease of the paranasal sinuses”. The Laryngoscope11 (1984): 1501-1508.
  53. Blackmore S., et al. “Influenza infection triggers disease in a genetic model of experimental autoimmune encephalomyelitis”. Proceedings of the National Academy of Sciences of the United States of America30 (2017): E6107-E6116.
  54. Boucher A., et al. “Long-term human coronavirus-myelin cross-reactive T-cell clones derived from multiple sclerosis patients”. Clinical Immunology3 (2007): 258-267.
  55. Mao L., et al. “Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China”. JAMA Neurology (2020).
  56. Ellegard EK. “Clinical and pathogenetic characteristics of pregnancy rhinitis”. Clinical Reviews in Allergy and Immunology3 (2004): 149-159.
  57. Dzieciolowska-Baran E., et al. “Rhinitis as a cause of respiratory disorders during pregnancy”. Advances in Experimental Medicine and Biology 755 (2013): 213-220.
  58. Dobson R., et al. “UK consensus on pregnancy in multiple sclerosis: ‘Association of British Neurologists’ guidelines”. Practical Neurology (2019): p. practneurol-2018-002060.
  59. Rejdak K., et al. “Multiple sclerosis: a practical overview for clinicians”. British Medical Bulletin1 (2010): 79-104.
  60. Rodríguez-Osorio X., et al. “Postictal sneeze: An old but still under-recognized epileptic symptom”. Seizure - European Journal of Epilepsy10 (2013): 911-912.
  61. Kelley BJ and M Rodriguez. “Seizures in patients with multiple sclerosis: epidemiology, pathophysiology and management”. CNS Drugs10 (2009): 805-815.
  62. Dean L. ACHOO Syndrome. (2012).
  63. Semes LP., et al. “The photic sneeze response: a descriptive report of a clinic population”. Journal of the American Optometric Association 6 (1995): 372-377.
  64. Lin TJ., et al. “Psychogenic intractable sneezing: case reports and a review of treatment options”. Annuals of Allergy Asthma Immunology6 (2003): 575-578.
  65. Swedo SE., et al. “Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases”. 155.2 (1998): 264-271.
  66. Teebi AS and QA al-Saleh. “Autosomal dominant sneezing disorder provoked by fullness of stomach”. Journal of Medical Genetics 8 (1989): 539-40.
  67. Hall JG. “The SNATIATION reflex”. Journal of Medical Genetics4 (1990): 275-275.
  68. Gore G and A Verma. “Sneezing–Physiological Facts and Beliefs”. The Journal of the Association of Physicians of India9 (2017): 106-106.
  69. Fakih R., et al. “Food allergies are associated with increased disease activity in multiple sclerosis”. Journal of Neurology, Neurosurgery, and Psychiatry (2018).
  70. Murphy AM., et al. “Prevalence of stress urinary incontinence in women with multiple sclerosis”. International Neurourology Journal2 (2012): 86.
  71. Yang W., et al. “Snap, crackle and pop: when sneezing leads to crackling in the neck”. BMJ Case Reports (2018): p. bcr-2016-218906.
  72. van der Kleij., et al. “Significance of Conversation between Mast Cells and Nerves”. Allergy, Asthma and Clinical Immunology 2 (2005): 65.
  73. Rozniecki JJ., et al. “Elevated mast cell tryptase in cerebrospinal fluid of multiple sclerosis patients”. Annals of Neurology1 (1995): 63-66.
  74. Huang G., et al. “Regulation of TH 17 cell differentiation by innate immune signals”. Cellular and Molecular Immunology4 (2012): 287-295.
  75. Widegren H., et al. “Effects of TNF<em>&#x3b1;</em> on the human nasal mucosa <em>in vivo</em>”. Respiratory Medicine9 (2007): 1982-1987.
  76. Bsteh G., et al. “Serum neurofilament light levels correlate with change of olfactory function in multiple sclerosis”. Multiple Sclerosis Journal - Experimental, Translational and Clinical4 (2019): 2055217319885987-2055217319885987.
×

Citation

Citation: Homayoun Roshanisefat. “Does Sneezing Play a Role in Multiple Sclerosis?". Acta Scientific Medical Sciences 4.8 (2020): 112-123.




Metrics

Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor0.851

Indexed In





News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is September 30, 2021.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US