Acta Scientific Medical Sciences (ISSN: 2582-0931)

Case Report Volume 4 Issue 6

Systemic Lupus Erythematosus and as Hemoglobinopathy: An Unusual Association about a Case in Lomé

Nemi Komi Dzidzonu1,2*, Abdou Razak Moukaila1, Komi Edem Mossi1, Lihanimpo Djalogue3,4, Abou-Bakari Tchala1, Yawovi Mawufemo Tsevi2,5 and Mohaman Awalou Djibril1,2

1Department of Internal Medicine, Sylvanus Olympio Teaching Hospital of Lomé, Lomé, Togo
2Faculty of Health Sciences, University of Lomé, Lomé, Togo
3Department of Internal Medicine, Kara Teaching Hospital, Lomé, Togo
4Faculty of Health Sciences, University of Kara, Togo
5Department of Nephrology, Sylvanus Olympio Teaching Hospital of Lomé, Lomé, Togo

*Corresponding Author: Nemi Komi Dzidzonu, Department of Internal Medicine, Sylvanus Olympio Teaching Hospital of Lomé, University of Lomé, Lomé, Togo.

Received: April 20, 2020; Published: May 31, 2020

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Abstract

We report a case of systemic lupus erythematosus in an adolescent with AS hemoglobinopathy, hospitalized from September 26 to October 20, 2018 in the internal medicine department of the Sylvanus Olympio teaching hospital of Lomé. It is a 17 years old girl, with a family history of sickle cell disease, hospitalized for a prolonged fever. The physical examination on admission noted: A fever at 40°C, a deterioration of the general state, a puffiness of the face with edema of the lower limbs, firm and painful adenopathies under chin and cervical, purpura, diffuse alopecia and non-deforming bilateral polyarthritis affecting the metacarpophalangeal and proximal interphalangeal joints. The biological assessment revealed an inflammatory syndrome, 24h proteinuria = 4,690 mg and hemoglobin AS, the native anti-DNA antibodies higher than 380 IU/ml. The diagnosis of systemic lupus erythematosus was made on the basis of at least 4 of the 11 criteria of the American College of Rheumatology 1997. The clinical manifestations of the lupus and AS hemoglobinopathy association in our patient are characterized by the absence of the major cutaneous-mucosal signs in particular the malar rush in butterfly wing, discoid lupus, photosensitivity and mouth or nasopharyngeal ulcerations.

Keywords: Lupus; Hemoglobinopathy; Lomé; Togo

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References

  1. Fattorusso V and Ritter O. “Le lupus érythémateux disséminé”. Vadémécum Clinique, Du diagnostic au traitement XVème Edition, Masson, Paris-Milan-Barcelone (1998): 1276-1278.
  2. Kombate K., et al. “le lupus systémique à Lomé, Togo”. Tropical Medicine 68 (2008): 283-286.
  3. Basset A., et al. “A propos d’un cas de lupus érythémateux disséminé”. Bulletins et mémoires de la Société Médicale des Hôpitaux 5 (1960): 172-175.
  4. Ka MM., et al. “Lupus érythémateux systémique au Sénégal”. Médecine d'Afrique Noire 45.1 (1998) :41-45.
  5. Diop MM., et al. “Les modes de révélation du lupus érythémateux systémique à Dakar (Sénégal) : à propos d’une série de 161 cas”. Revue Africaine de Médecine Interne 1.2 (2014): 12-15.
  6. Reggany T. “Lupus érythémateux systémique : aspects épidémio-cliniques, biologiques et évolutifs au cours des consultations dans le service de rhumatologie au CHU du Point G”. Thèse de Médecine Université de Bamako (2006): 112.
  7. Zomalheto Z., et al. “Lupus érythémateux systémique : Particularités au Bénin et en Afrique de l’Ouest”. La Tunisie Médicale 92.12 (2014): 707-710.
  8. Azon-Kouanou A., et al. “Profil clinique et biologique des patients lupiques suivis au centre national hospitalier et universitaire Hubert Koutoukou Maga de Cotonou”. Journal de la Société de Biologie Clinique du Bénin 23 (2015): 41-50.
  9. Maamar M., et al. “Drépanocytose et lupus systémique: une association rare”. La revue de Médecine Interne 33 (2012) : S195.
  10. Robazzi TCMV., et al. “Coexisting systemic lupus erythematosus and sickle cell disease: case report and littérature review”. Revista Brasileira de Reumatologia 55.1 (2015): 68-74.
  11. Lopez P., et al. “Epidemiology of systemic lupus erythematosus in northern Spanish population : Gender and age affluence on immunological features”. Lupus 12.11 (2003): 860-865.
  12. Adelowo Oo., et al. “Auto antibodies in Nigerian lupus patients”. African Journal of Medicine and Medical Sciences 41 (2012): 177-181.
  13. George A and Ogunbiyi A. “Systemic lupus erythemaatosus among a rarity in West Africa, or a yet to be investigates entity”. Lupus 14 (2005): 924-925.
  14. Teclessou Nj., et al. “Maladie lupique en milieu hospitalier à Lomé: Etude rétrospective de 116 cas”. Revue Africaine de Médecine Interne 4.1-1 (2017): 19-23.
  15. Ghedira I., et al. “Clinical and serological characteristics of systemic lupus erythematosus: 128 cases”. Pathologie Biologie 50 (2002): 18-24.
  16. Monnier A., et al. “Le lupus érythémateux aigu disséminé en Côte d’Ivoire. A propos de 9 observations”. Tropical Medicine 45 (1985): 47-54.
  17. Louzir B., et al. “Le lupus érythémateux systémique en Tunisie : Etude multicentrique nationale: A propos de 295 Observations”. La Revue de Médecine Interne (2000): 21.
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Citation

Citation: Nemi Komi Dzidzonu., et al. “Systemic Lupus Erythematosus and as Hemoglobinopathy: An Unusual Association about a Case in Lomé". Acta Scientific Medical Sciences 4.6 (2020): 141-144.



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