Acta Scientific Medical Sciences (ISSN: 2582-0931)

Research Article Volume 4 Issue 5

Evaluation of Analgesic Activity of Some Novel Quinazolinone Analogues

Ritesh Patel1*, Rohit Saraswat2 and Sujit Pillai3

1Indore Institute of Pharmacy, Indore, MP, India
2Department of Pharmacy, OPJS University, Churu, RJ, India
3GRY Institute of Pharmacy, Khargone, MP, India

*Corresponding Author: Ritesh Patel, Indore Institute of Pharmacy, Indore, MP, India.

Received: April 11, 2020; Published: May 04, 2020

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Abstract

  The synthesis, characterization and spectroscopic studies of new quinazolinone substituted analogues Q1 - Q16 with analgesic activity were described. A series of novel quinazolinone derivatives were synthesized. In this view, 5-chloro anthranilic acid undergoes acetylation in the presence of acetic anhydride and anhydrous sodium acetate to give 5-chloro-N-acetyl anthranilic acid as intermediate-I which upon cyclization in the presence of phosphorous pentaoxide, glacial acetic acid and para amino benzoic acid to yield 4-[6-chloro-2-methyl-4-oxoquinazolin-3(4H)-yl] benzoic acid as intermediate-II. This resulted intermediate-II undergo mannich base reaction to produce novel quinazolinone derivatives on reaction of formaldehyde with different aromatic amines. All the synthetic derivatives were fully characterized by spectral analytical data (elemental analysis, FTIR, 1H NMR and Mass) and the purity of the compounds was determined by TLC. Analgesic activities were tested via both hot plate and acetic acid induced writhing methods. The study concluded that the compound Q5, Q8 and Q9 were found to exhibit significant analgesic activity when compared to Ibuprofen as standard drug while other derivatives exhibit moderate to good analgesic activity.

Keywords:5-Chloro Anthranilic Acid; Quinazolinone; Analgesic Activity; Ibuprofen

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Citation

Citation: Ritesh Patel., et al. “Evaluation of Analgesic Activity of Some Novel Quinazolinone Analogues". Acta Scientific Medical Sciences 4.5 (2020): 89-96.




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