Prerna Chaturvedi1*, PK Dubey2 and Birendra Shrivastava1
1Department of Pharmaceutical Sciences, Jaipur National University, Jaipur,
2Swami Vivekanand College of Pharmacy, Indore, Madhya Pradesh, India
*Corresponding Author: Prerna Chaturvedi, Department of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India
Received: April 09, 2020; Published: May 04, 2020
At present drug discovery includes the identification of screening hits, medicinal chemistry and optimization of these hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life) and oral bioavailability. Antimicrobial agents are any variety of c compounds that can destroy or prevent the growth of microorganisms. In the present paper antimicrobial activity of 5-(6-(2,4-dichlorophenyl)-[1,2,4]triazolo[3,4-b][1,3,4] thiadiazol-3-yl)benzene-1,2,3-triol was screened for antimicrobial activity against two representatives of Gram-positive bacteria viz. S. aureus, B. subtilis, two Gram-negative bacteria viz. E. coli, P. aeruginosa and two fungi viz. C. albicans, A. niger by the broth microdilution MIC method. Results suggest that the compound possess optimum activity when compared with standard drug.
Keywords:Anti-Microbial; Triazolo-Thiadiazole Derivative; Standard Drug
Citation: Prerna Chaturvedi. “Investigation of Anti-Microbial Activity of 5-(6-(2,4-Dichlorophenyl)-[1,2,4]Triazolo[3,4-b][1,3,4] Thiadiazol-3-yl) Benzene-1,2,3-Triol". Acta Scientific Medical Sciences 4.5 (2020): 87-88.
Copyright: © 2020 Prerna Chaturvedi. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.