Acta Scientific Medical Sciences (ISSN: 2582-0931)

Research Article Volume 4 Issue 5

The Relation of Helicobacter pylori Infection to Gastric Cancer

Abdulaziz Radhi S ALjohni1,2, Bassam Oudh Al Johny1* and Mohamed Morsi M Ahmed1,3

1Department of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia
2Department of Laboratory at King Fahad Hospital, Medina, Kingdom of Saudi Arabia
3Nucleic Acids Research Department, Genetic Engineering, and Biotechnology Research Institute (GEBRI), Mubarak City for Scientific Research and Technology Applications, Alexandria, Egypt

*Corresponding Author: Bassam Oudh Al Johny, Department of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.

Received: March 03, 2020; Published: April 23, 2020



Background: Helicobacter pylori (H.P.) is a very common bacteria that affect half of the population. It has been incriminated in cancer stomach and gastric lymphoma.

Objective: This work aims to discuss the relation and mechanism of H.P. in causing gastric carcinoma.

Review of Literature: H.P. has different methods of transmission like oral-oral, fecal-oral, gastro-oral and gastro gastric. The microbiological features of H.P. support its growth and protect it from oxidative damage that enhancing its survival rate. H.P. is now determined as one of the most critical carcinogenic infectious agents because it's a high risk of developing stomach cancer. Gastric cancer is the third type of cancer leading to death and it is due to different causes and risk factors. There are many factors affect the outcome of patients who had infected with H.P. and increase the risk of developing cancer. These are environmental, host-related and virulence factors. All of these factors participate in the development of gastric cancer by two mechanisms, direct inflammatory effects and indirect through mutations in the cell-cycle regulating genes.

Conclusion: H.P. infection has an important carcinogenic role in the development of cancer stomach. Eradication of H.P. will decrease the risk of developing stomach cancer.

Keywords: Helicobacter pylori; Gastric Cancer; Transmission; Infection; Relation



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Citation: Bassam Oudh Al Johny.,et al. “The Relation of Helicobacter pylori Infection to Gastric Cancer Acta Scientific Medical Sciences 4.5 (2020): 54-59.


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