Acta Scientific Medical Sciences (ISSN: 2582-0931)

Case Report Volume 4 Issue 5

Unusual Histological Variant of a Primary Osseous Tumor of the Jaw in a 27-Year-Old Female: Review of the Literature and Case Presentation

Erisa Kola1*, Leart Berdica1,2, Teona Bushati1,2, Alfred Aga3, Ali Guy4, Ina Kola5, Edlira Horjeti6, Klejda Hoxha7, Fareeha Nasir8 and Juna Musa9

1Department of Pathology and Forensic Medicine, Faculty of Medicine, UMT, Tirane, Albania
2Department of Pathology, American Hospital, Tirane, Albania
3Department of Head and Neck surgery, American Hospital, Tirana, Albania
4Department of Physical Medicine and Rehabilitation, New York University, School of Medicine-NYU, New York, USA
5Department of Plastic Surgery and Burns, Mother Teresa Hospital Center, Tirane, Albania
6Family Doctor, Department of Family Medicine, Tirane, Albania
7Medical Doctor, Family Medicine. Tirane, Albania
8Intern, Department of Surgery, Christian Hospital Quetta, Pakistan
9Postdoctoral Research Fellow, Department of Robotic Surgery, Mayo Clinic, Minnesota

*Corresponding Author: Erisa Kola, Department of Pathology and Forensic Medicine, Faculty of Medicine, UMT, Tirane, Albania.

Received: April 10, 2020; Published: April 21, 2020

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Abstract

Introduction: Osteosarcoma is the most common primary malignant bone tumor and represents 20% of head and neck malignancies. Meanwhile osteosarcoma of the jaw is a rare entity, distinct from the conventional type commonly arising in the long bones. According to literature it comprises 6.5 - 7% of all osteosarcomas. WHO has acknowledged several variants of osteosarcoma that differ in location, clinical manifestation and the degree of cytologic atypia [1]. These lesions can arise de novo and present as primary bone tumors, or in a pre-excisting condition such as previous head and neck radiation. Also, hereditary retinoblastoma, Paget’s disease of bone, previous history of fibrous dysplasia, or trauma has been associated with the development of osteosarcomas. From a histopathologic point of view, osteosarcomas are commonly classified as osteoblastic, chondroblastic, or fibroblastic, although several unusual microscopic subtypes have also been reported.

Material and Methods: The aim of this article is to highlight the importance of clinical, radiological and histopathologic correlations in order to reach an accurate definite diagnosis in the setting of effective surgical management of this kind of lesions. We share our experience presenting a case of chondroblastic variant of osteosarcoma of the maxilla in a 27-year-old woman, and a critical review of the literature.

Conclusion: Osteosarcoma of the jaw is challenging both to diagnose and manage. The biological behavior of osteosarcomas in the jaws differs from tumors of other skeletal bones. Histopathological examination with adequate specimen evaluation is the key to accurate diagnosis and staging. Microscopically, the essential criterion of osteosarcomas is direct production of osteoid or immature bone by tumor cells. Osteosarcoma should always be considered in the differential diagnosis of expansile lesions of the jaws. Hence, early diagnosis and adequate surgical resection are the keys to better survival.

Keywords: Osteosarcoma; Chondroblastic Osteosarcoma; Osteosarcoma of Maxilla; Osseous Tumors

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References

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Citation

Citation: Erisa Kola., et al. “Unusual Histological Variant of a Primary Osseous Tumor of the Jaw in a 27-Year-Old Female: Review of the Literature and Case Presentation". Acta Scientific Medical Sciences 4.5 (2020): 45-48.



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