Acta Scientific Medical Sciences (ISSN: 2582-0931)

Case Report Volume 4 Issue 4

Neuropathic Pain in A Patient with Relapsing-Remitting Multiple Sclerosis – A Case Report

Goce Kalcev1*, Ivan Barbov1 and Elizabeta Zisovska2

1University Clinic for Neurology, Skopje, Republic of North Macedonia
2University Clinic for Gynecology and Obstetrics, Skopje, Republic of North Macedonia

*Corresponding Author: Goce Kalcev, University Clinic for Neurology, Skopje, Republic of North Macedonia.

Received: February 14, 2020; Published: March 06, 2020



  Multiple sclerosis (MS) is an autoimmune disorder characterized by immune cell infiltration and inflammation within the central nervous system (CNS) causing progressive demyelination and neurodegeneration. Neuropathic pain in patients with MS is of central origin. It is well known that neuropathic pain has a negative impact on MS patients’ quality of life. Therefore, we present a case of a 40- year-old man from Republic of North Macedonia with Relapsing-remitting MS (RRMS). The patient was asked to evaluate how the neuropathic pain influenced the enjoyment of life, daily activity, walking, mood, sleep, work and relations with others. This type of pain mostly interfered with patient enjoyment of life. Clearly, neuropathic pain generally disturbs the comfort of patients with multiple sclerosis.

Keywords: Multiple Sclerosis; Neuropathic Pain; Evaluation; Demyelination; Neurodegeneration



  1. McKinney EF., et al. “Tcell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection”. Nature 523 (2015): 612-622. 
  2. Dendrou CA., et al. “Immunopathology of multiple sclerosis”. Nature Reviews Immunology 15 (2015): 545-558. 
  3. Jakob E., et al. “Uveitis subtypes in a German interdisciplinary uveitis center–analysis of 1916 patients”. The Journal of Rheumatology 36.1 (2009):127-136. 
  4. Goldenberg MM. “Multiple sclerosis review”. PT 37 (2012): 175-184.  
  5. Foley PL., et al. “Prevalence and natural history of pain in adults with multiple sclerosis: systematic review and meta-analysis”. Pain 154 (2013): 632-642. 
  6. Martinelli Boneschi F., et al. “Lifetime and actual prevalence of pain and headache in multiple sclerosis”. Multiple Sclerosis Journal 14 (2008): 514-521. 
  7. CH Marck., et al. “Physical activity and associated levels of disability and quality of life in people with multiple sclerosis: a large international survey”. BMC Neurology 14.1 (2014). 
  8. A Rintala., et al. “Ten-year follow-up of health-related quality of life among ambulatory persons with multiple sclerosis at baseline”. Quality of Life Research 25.12 (2016): 3119-3127. 
  9. Sarraf P., et al. “Relationship between Sleep Quality and Quality of Life in Patients with Multiple Sclerosis”. International Journal of Preventive Medicine 12 (2014): 1582. 
  10.   Jensen TS., et al. “A new definition of neuropathic pain”. Pain 152 (2011): 2204-2205.
  11. Scholz J., et al. “The IASP classification of chronic pain for ICD-11: Chronic neuropathic pain”. Pain 160 (2019): 53-59. 


Citation: Goce Kalcev., et al. “Neuropathic Pain in A Patient with Relapsing-Remitting Multiple Sclerosis – A Case Report". Acta Scientific Medical Sciences 4.4 (2020): 25-27.


Acceptance rate30%
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