Acta Scientific Medical Sciences (ISSN: 2582-0931)

Research Article Volume 4 Issue 3

Correction of Insulin Resistance and Glucose Tolerance in Rats with Alloxan-Induced Diabetes Mellitus

Kozlova AP, Koroshchenko GA and Aizman RI*

Anatomy, Physiology and Life Safety, Novosibirsk State Pedagogical University, Novosibirsk, Russia

*Corresponding Author: Aizman RI, Anatomy, Physiology and Life Safety, Novosibirsk State Pedagogical University, Novosibirsk, Russia.

Received: January 17, 2020; Published: February 14, 2020

×

Abstract

  Currently, diabetes mellitus (DM) has become one of the most common non-infectious pathologies, often causing complications in the cardiovascular system, kidneys, vision, nervous system, etc., which leads to early disability and mortality of people at the working age [1,2]. The constant increase in the cost of treatment of patients with this disease is a heavy burden on health care, so it becomes obvious that there is a need to find and develop facilities to reduce the prevalence of diabetes and its complications.

Keywords: Diabetes Mellitus; Correction of Insulin; Resistance and Glucose Tolerance

×

References

  1. The IDF diabetes Atlas. Ninth edition (2019). 
  2. Dedov II., et al. “Diabetes mellitus in the Russian Federation: prevalence, morbidity, mortality, parameters of carbohydrate metabolism and structure of sugar-lowering therapy according to the Federal register of diabetes mellitus, status 2017”. Diabetes Mellitus 21.3 (2018): 144-159. 
  3. Mozheiko LA. “Experimental models for the study of diabetes mellitus. Part 1. Alloxan diabetes”. Journal of the Grodno State Medical University 3 (2013): 26-29. 
  4. Etuk EU. “Animals models for studying diabetes mellitus”. Agriculture and Biology Journal of North America 1.2 (2010): 130-134. 
  5. Mikhailichenko VYu and Stolyarov SS. “The Role of insulin and counterinsular hormones in the pathogenesis of alloxan diabetes mellitus in rats in the experiment”. Modern Problems of Science and Education 4 (2015):  485. 
  6. Aizman RI., et al. “The mechanisms of plant Curcuma longa rhizome action on carbohydrate metabolism in alloxan - induced diabetes mellitus rats”. American Journal of Biomedical Research 3 (2015):  1-5. 
  7. Islam MS and Loots Du T. “Experimental rodent models of type 2 diabetes: a review”. Methods and Findings in Experimental and Clinical Pharmacology 31.4 (2009): 249-261. 
  8. Yarmolinskaya M. I., et al. “Experimental models of type 1 diabetes”. Journal of Obstetrics and Women's Diseases 68.2 (2019) 109-118.
  9. Shilov A., et al. “Cherepanova Insulin resistance, glucose intolerance, and their correction in patients with metabolic syndrome”. Doctor 2 (2011): 16-20. 
  10. Nikonova LG., et al. “Reaction of the pancreas of dogs with impaired glucose tolerance to physical activity of different intensity”. Morphology 142.4 (2012): 72-77.
  11. Diabetes Association. “Diabetes and classification of diabetes mellitus”. Diabetes Care 27.1 (2004): 15-110. 
  12. Jafarova RE., et al. “Effects of bilberry leaf extract on the course of the pathological process of alloxan-induced diabetes mellitus”. Fundamental Research 4 (2010): 36-43. 
  13. Mitrofanova IYu., et al. “Methodological bases of selection of plant objects as sources of phytopreparations”. Fundamental Study 10 (2012): 405-408.
  14. Kozlova AP., et al. “What components of the plant Curcuma longa have a hypoglycemic effect in diabetes?” Bulletin of the Novosibirsk State Pedagogical University 3 (2016): 167-175. 
  15. Bonte F., et al. “Protective effect of curcuminoids on epidermal skin cells under free oxygen radical stress”. Planta Medica 63.3 (1997): 265-266. 
  16. Lutomski J., et al. “Effect of an alcohol extract and of active ingredients from Curcuma longa on bacteria and fungi”. Planta Medica 26.1 (1974): 9-19. 
  17. Ghatak N and Basu N. “Sodium curcuminate as an effective anti-inflammatory agent”. Indian Journal of Experimental Biology   10.3 (1972): 235-236. 
  18. Babu PS and Srinivasan K. “Hypolipidemic action of curcumin, the active principle of turmeric (Curcuma longa) in streptozotocin induced diabetic rats”. Molecular and Cellular Biochemistry 166.1-2 (1997): 169-175. 
  19. Kozlova AP., et al. “Prevention and correction of carbohydrate metabolism disorders in diabetes mellitus as a medical and social problem of healthy lifestyle formation: experimental justification”.  Science for Education Today 1 (2019): 208-225. 
  20. Khajehdehi P., et al. “Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled study”. Scandinavian Journal of Urology and Nephrology 45 (2011): 365-370.
×

Citation

Citation: Aizman RI., et al. “Correction of Insulin Resistance and Glucose Tolerance in Rats with Alloxan-Induced Diabetes Mellitus". Acta Scientific Medical Sciences 4.3 (2020): 01-04.



Member In





News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 10, 2020.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US