Acta Scientific Medical Sciences (ISSN: 2582-0931)

Research Article Volume 4 Issue 1

Renoprotective, Hypoglycemic, and Hypolipidemic Effects of Argan (Argania Spinosa L.) Oil in Male Rats Exposed to Cadmium

Mujahid M Al-Muqati, Isam M Abu Zeid* and Naser A Al-Kenani

Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, Saudi Arabia

*Corresponding Author: Isam M Abu Zeid, Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, Saudi Arabia.

Received: December 26, 2019; Published: December 31, 2019


  The protective and health benefits of various plant oils as Reno protective, hypoglycemic, and hypolipidemic agents are recently receiving considerable attention. The objective of the present study is to evaluate the protective effect of argan oil on male rats exposed to cadmium (Cd). In this study, 48 male rats were equally allocated into 4 groups. Rats of the first group (G1) served as normal controls. Rats of the second group (G2) were orally given 5mg/kg body weight cadmium chloride day after day. Rats the third group (G3) were orally administered with 700 mg/kg body weight argan oil and after three hours gave the same dose of cadmium chloride given to group two. Rats of the fourth group were orally supplemented with the same dose of argan oil given to group three. After six weeks of treatment, aassessments of fasting blood glucose, and serum urea nitrogen, uric acid, creatinine, low density lipoprotein-cholesterol (LDL-c) and high density lipoprotein-cholesterol (HDL-c) were performed in control and cadmium-intoxicated rats. Rats exposed to Cd showed increased levels of serum uric acid, creatinine and LDL-c compared with the normal control group. Alterations in the studied parameters were observed in cadmium-intoxicated rats administered with argan oil. Supplemented cadmium-intoxicated rats showed near normal biochemical profile and well preserved renal histology that substantiate the Reno protective, antihyperglycemic, and antihyperlipidemic effects of argan oil in rats exposed to cadmium chloride.

Keywords: Argan Oil; Cadmium; Nephropathy; Hypoglycemic; Hypolipidemic Effect



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Citation: Isam M Abu Zeid., et al. “Renoprotective, Hypoglycemic, and Hypolipidemic Effects of Argan (Argania Spinosa L.) Oil on Male Rats Exposed to Cadmium". Acta Scientific Medical Sciences 4.1 (2020): 32-41.


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