Acta Scientific Microbiology

Review Article Volume 7 Issue 8

Unveiling the Chemical Cocktail Conundrum: A Theoretical Exploration of Environmental Pollution and Zoonotic Spillover in Mammals

Lamlom Taie Lamlom Tahawy*

Bioscience Study Program, Graduate Program, Universitas Sebelas Maret, Surakarta, Indonesia

*Corresponding Author: Lamlom Taie Lamlom Tahawy, Bioscience Study Program, Graduate Program, Universitas Sebelas Maret, Surakarta, Indonesia.

Received: June 03, 2024; Published: July 26, 2024

Abstract

The rise of zoonotic diseases, such as COVID-19, highlights the urgent need for an integrated One Health approach that bridges animal, human, and environmental health. This paper proposes a theoretical framework to examine the role of environmental contaminants, particularly chemical cocktails, in facilitating zoonotic spillover events in mammals. Our conceptual model focuses on the synergistic effects of chemical pollution and zoonotic pathogens on wildlife and human health, incorporating the following elements: a representative mix of immunotoxic environmental contaminants like perfluorinated substances (PFAS), diverse mammalian species as potential wildlife reservoir hosts, various zoonotic viruses with different transmission dynamics, and the theoretical impact of chemical exposure on wildlife immune systems potentially increasing susceptibility to zoonotic pathogens. We hypothesize that combined stressors, such as chemical exposure and infectious diseases, might drive viral adaptation and enhance zoonotic spillover potential to humans.

Keywords: Integrated One Health Approach; Chemical Contaminants; Zoonotic Spillover; Synergistic Effects

References

  1. YY Liu. “Controlling the human microbiome”. Cell Systems2 (2023): 135-159.
  2. W Gou., et al. “Nutri-microbiome epidemiology, an emerging field to disentangle the interplay between nutrition and microbiome for human health”. Protein and cell11 (2023): 787-806.
  3. K Narasimha Varma. “The Impact of the Human Microbiome on Mental Health: A Systemic Review”.
  4. S J Bultman. “Emerging roles of the microbiome in cancer”. Carcinogenesis2 (2014): 249-255.
  5. TW Grunt and P Valent. “Cancer - A devastating disease, but also an eye-opener and window into the deep mysteries of life and its origins”. Progress in Biophysics and Molecular Biology 175 (2022): 131-139.
  6. S Parida and D Sharma. “The microbiome and cancer: Creating friendly neighborhoods and removing the foes with in A C”. Cancer Research4 (2021): 790-800.
  7. DC Hinshaw and L A Shevde. “The tumor microenvironment innately modulates cancer progression”. Cancer Research18 (2019): 4557-4567.
  8. JA Wargo., et al. “Modulating the microbiome to improve therapeutic response in cancer”. (2019).
  9. B Oh., et al. “Emerging Evidence of the Gut Microbiome in Chemotherapy: A Clinical Review”. Frontiers in Oncology 11 S.A (2021).
  10. E Elinav., et al. “The cancer microbiome”. Nature Reviews Cancer7 (2019): 371-376.
  11. J L Fessler and T F Gajewski. “The Microbiota: A New Variable Impacting Cancer Treatment Outcomes”. Clinical Cancer Research13 (2017): 3229-3231.
  12. A Sevcikova., et al. “The impact of the microbiome on resistance to cancer treatment with chemotherapeutic agents and immunotherapy”. International Journal of Molecular Sciences1 (2022).
  13. A Tzeng., et al. “Human breast microbiome correlates with prognostic features and immunological signatures in breast cancer”. Genome Medicine1 (2021).
  14. F Avilés-Jiménez., et al. “On the Search to Elucidate the Role of Microbiota in the Genesis of Cancer: The Cases of Gastrointestinal and Cervical Cancer”. Archives of Medical Research8 (2017): 754-765.
  15. GD Sepich-Poore., et al. “The microbiome and human cancer”. Science 6536 (2021).
  16. V Gopalakrishnan., et al. “The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy”. Cancer Cell 4. (2018): 570-580.
  17. A Sevcikova., et al. “The impact of the microbiome on resistance to cancer treatment with chemotherapeutic agents and immunotherapy”. International Journal of Molecular Sciences 1 (2022).
  18. SL Picardo., et al. “The microbiome and cancer for clinicians”. Critical Reviews in Oncology/Hematology 141 (2019): 1-12.
  19. A Laborda-Illanes., et al. “Breast and gut microbiota action mechanisms in breast cancer pathogenesis and treatment”. Cancers (Basel)9 (2020): 1-27.
  20. SE Shelton., et al. “iScience Engineering approaches for studying immune-tumor cell interactions and immunotherapy”. (2019).
  21. A Boussommier-Calleja., et al. “Microfluidics: A New Tool for Modeling Cancer-Immune Interactions”. Trends in Cancer1 (2016): 6-19.
  22. N Ivanenko. “BIOFILM AND TUMOR: INTERPRETATION OF INTERACTION AND TREATMENT STRATEGIES. Review”. Medical Science of Ukraine (MSU)1 (2021): 104-120.
  23. S Vivarelli., et al. “Gut microbiota and cancer: From pathogenesis to therapy”. Cancers1 (2019).
  24. H Zhou., et al. “Host-microbiome protein-protein interactions capture disease-relevant pathways”. Genome Biology1 (2022).
  25. SB Amatya., et al. “Bacterial extracellular vesicles in gastrointestinal tract cancer: An unexplored territory”. Cancers21 (2021).
  26. C H Johnson., et al. “Metabolism links bacterial biofilms and colon carcinogenesis”. Cell Metabolism6 (2015): 891-897.
  27. Y Chen and YX Chen. “Microbiota-associated metabolites and related immunoregulation in colorectal cancer”. Cancers16 (2021).
  28. A Limeta., et al. “Meta-analysis of the gut microbiota in predicting response to cancer immunotherapy in metastatic melanoma”. JCI Insight 23 (2022).
  29. A Aghamajidi and S Maleki Vareki. “The Effect of the Gut Microbiota on Systemic and Anti-Tumor Immunity and Response to Systemic Therapy against Cancer”. Cancers 15 (2022).
  30. V Sethi., et al. “Gut Microbiota Promotes Tumor Growth in Mice by Modulating Immune Response”. Gastroenterology1 (2018): 33-37.e6.
  31. T Zhan., et al. “Wnt signaling in cancer”. Oncogene11 (2017): 1461-1473.
  32. B Ma and MO Hottiger. “Crosstalk between wnt/β-catenin and NF-κB signaling pathway during inflammation”. Frontiers in Immunology 7 (2016).
  33. B Hoesel and JA Schmid. “The complexity of NF-κB signaling in inflammation and cancer”. Molecular Cancer1 (2013).
  34. MC Markowski., et al. “The Microbiome and Genitourinary Cancer: A Collaborative Review”. European Urology4 (2019): 637-646.
  35. A Sevcikova., et al. “The impact of the microbiome on resistance to cancer treatment with chemotherapeutic agents and immunotherapy”. International Journal of Molecular Sciences 1 (2022).
  36. V Matson., et al. “Cancer and the Microbiome—Influence of the Commensal Microbiota on Cancer, Immune Responses, and Immunotherapy”. Gastroenterology2 (2021): 600-613.
  37. E Saus., et al. “Microbiome and colorectal cancer: Roles in carcinogenesis and clinical potential”. Molecular Aspects of Medicine 69 (2019): 93-106.
  38. A Tzeng., et al. “Human breast microbiome correlates with prognostic features and immunological signatures in breast cancer”. Genome Medicine 1 (2021).
  39. A Tzeng., et al. “Human breast microbiome correlates with prognostic features and immunological signatures in breast cancer”. Genome Medicine 1 (2021).
  40. Z Liu., et al. “Multi-Omics Analysis Reveals Intratumor Microbes as Immunomodulators in Colorectal Cancer”. Microbiology Spectrum 2 (2023).
  41. P Wu., et al. “Profiling the urinary microbiota in male patients with bladder cancer in China”. Frontiers in Cellular and Infection Microbiology 8 (2018).
  42. T Reynolds., et al. “Microbiome Contributions to Health”. Surgical Infectious (Larchmt) 24.3 (2023): 213-219.
  43. S S Kaushal., et al. “Watershed ‘chemical cocktails’: forming novel elemental combinations in Anthropocene fresh waters”. Biogeochemistry3 (2018): 281-305.
  44. F Chassagne., et al. “Validation of a 16th century traditional Chinese medicine use of ginkgo biloba as a topical antimicrobial”. Frontiers in Microbiology 10 (2019).
  45. D J Spurgeon., et al. “Systems toxicology approaches for understanding the joint effects of environmental chemical mixtures”. Science of the Total Environment18 (2010): 3725-3734.
  46. Y Li., et al. “Crosstalk Between the Gut and Brain: Importance of the Fecal Microbiota in Patient With Brain Tumors”. Frontiers in Cellular and Infection Microbiology 12 (2022).

Citation

Citation: Lamlom Taie Lamlom Tahawy. “Unveiling the Chemical Cocktail Conundrum: A Theoretical Exploration of Environmental Pollution and Zoonotic Spillover in Mammals".Acta Scientific Microbiology 7.8 (2024): 124-135.

Copyright

Copyright: © 2024 Lamlom Taie Lamlom Tahawy. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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