Attapon Cheepsattayakorn1,2*, Ruangrong Cheepsattayakorn3 and Porntep Siriwanarangsun1
1Faculty of Medicine, Western University, Pathumtani Province, Thailand
210th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand
3Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
*Corresponding Author: Attapon Cheepsattayakorn, 10th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand.
Received: October 22, 2021 ; Published: November 01, 2021
ORF3a, nucleocapsid phosphoprotein (N), and envelop protein (E) of SARS-CoV-2 (COVID-19) have been demonstrated by conserved domain analysis that they had heme-associated sites . Ile304 of N, Cys44 of E, and Arg134 of ORF3a were the heme-iron-linked sites, whereas ORF3a possessed the conserved domains of bacterial EFeB protein and human cytochrome C reductase and could dissociate the iron of heme to form porphyrin . ORF3a was specific and did not attack peroxide, normal cytochrome C, and blue blood protein and it would increasingly cause less hemoglobin levels, so developing manifestations of coagulation reaction, respiratory distress, and finally damaging many tissues and organs . ORF3a, ORF10, and orf1ab could attack the 1-beta chain of hemoglobin, whereas some non-structural and structural viral proteins could bind porphyrin . Heme-linked sites of N protein and E protein may be associated with virus replication and high virus infectivity, respectively .
Citation: Attapon Cheepsattayakorn., et al. “Prediction of COVID-19 Severity by Hematological Parameters" Acta Scientific Microbiology 4.11 (2021): 82-94.
Copyright: © 2021 Ansab Akhtar. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.