Abstract

Leaf extracts from three species of Senna viz., S. alata, S. occidentalis, and S. alexandrina induced severe morphological alterations in the zoonotic cestode parasite Hymenolepis diminuta. The present study revealed the anthelmintic effects of these plant extracts on the major tegumental enzymes, acid phosphatase (AcPase), alkaline phosphatase (AlkPase), adenosine tri-phosphatase (ATPase) and 5’nucleotidase (5’- Nu) of H. diminuta. The effects have been established by making histochemical localization and biochemical quantification of the tegumental enzyme activities that form the basis of the present communication and would therefore add an in depth understanding to the prior findings. Reduction of enzyme level of more than 20%, 30%, 40% and 50% of AlkPase, AcPase, ATPase and 5’- Nu respectively were observed in plant extract treated parasites compared to control. This study thus opens new insight of the anthelmintic potential of the three species of Senna and ensures more mechanistic throughput in terms of anthelmintic drug discovery.

Keywords: Parasites; Histochemical; Biochemical; Anthelmintic; Tegument

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Citation

Citation: Suman Kundu, Sudeshna Mandal, Chandrani Mondal and Larisha Mawkhlieng Lyndem. “Alteration in the Tegumental Enzymes of Hymenolepis diminuta by Senna spp”. Acta Scientific Microbiology 4.11 (2021): 39-45.

Copyright

Copyright: © 2021 Suman Kundu., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.