Acta Scientific Microbiology (ISSN: 2581-3226)

Review Article Volume 4 Issue 11

How Common is Gain of Function

Vidya Raghunathan*

Central Instrument Facility, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India

*Corresponding Author: Vidya Raghunathan, Central Instrument Facility, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India. Email: vraghuna@nii.ac.in

Received: October 01, 2021 ; Published: October 18, 2021

×

Abstract

Evolution as we know from the time of Darwin C and Wallace AR moves in the direction of the survival of the fittest. With progressively greater understanding of biological systems and the microenvironment inside a cell, biological fitness at the molecular level has come to the fore. Evolution of metabolic regulation in parasites, as an adaptation to their respective environmental challenges is a case in point [1]. Kinetoplastida’s intracellular organelle the glycosome that sequesters over a thousand proteins, is thought to have assisted in the metabolic adaptability and acquisition of parasitism [2].

Keywords: Glycosome; Leishmania mexicana

×

References

  1. Fernandes PM., et al. “Kinetic and structural studies of Trypanosoma and Leishmania phosphofructokinases show evolutionary divergence and identify AMP as a switch regulating glycolysis versus gluconeogenesis”. FEBS Journal13 (2020): 2847-2861.
  2. Gualdron-Lopez M., et al. International Journal for Parasitology 42 (2012): 1-20.
  3. Eldeeb MA., et al. Trends in Biochemical Sciences 3 (2019): 181-183.
  4. Rorick MM and Wagner GP. Genome Biology and Evolution 3 (2011): 456-475
  5. Goldstein RA., et al. Molecular Biology and Evolution 6 (2015): 1373-1381.
  6. Tokuriki N and Tawfik DS. Current Opinion in Structural Biology 19 (2009): 596-604.
  7. Sanchiz A., et al. “The Experimental Proteome of Leishmania infantum Promastigote and Its Usefulness for Improving Gene Annotations”. Genes 11 (2020): 1036.
  8. Santiago M., et al. “Discovery, Molecular Mechanisms, and Industrial Applications of Cold-Active Enzymes”. Frontiers in Microbiology 7 (2016): 1408.
  9. Gupta A and Adami C. PLOS Genetics 12 (2016): e1005960.
  10. Biswas S., et al. “Regulation of Leishmania major PAS domain-containing phosphoglycerate kinase by cofactor Mg2+ ion at neutral pH”. FEBS Journal (2020).
  11. Ebbinghaus S., et al. Nature Mathematics 7 (2010): 319-323.
  12. Kaushik S., et al. Molecular and Biochemical Parasitology 185 (2012): 27-35.
  13. Srinivasan S., et al. Allergy, Drugs and Clinical Immunology ADCI1 (2018): 44-55.
  14. Sabelko J., et al. Proceedings of the National Academy of Sciences of the United States of America11 (1999): 6031-6036.
  15. Osvath S., et al. Journal of Molecular Biology 333 (2003): 187-199.
  16. Jamdhade MD., et al. OMICS: A Journal of Integrative Biology 3 (2015): 157-170.
  17. Senes A., et al. Journal of Molecular Biology 296 (2000): 921-936.
  18. Tokuriki N., et al. Science 324 (2009): 203-207.
  19. Saitou N and Nei M. Molecular Biology and Evolution 1 (1986): 57-74.
  20. G Thomas. Nature Reviews Molecular Cell Biology 10 (2002): 753-766.
  21. Coutard B., et al. Antiviral Research 176 (2020): 104742.
  22. Papa G., et al. Plos Pathogens1 (2021): e1009246.
  23. Feller G. “Psychrophilic Enzymes: From Folding to Function and Biotechnology”. Scientifica (Cairo) (2013).
  24. Rawson PD and Burton RS. Proceedings of the National Academy of Sciences of the United States of America 99 (2002): 12955-12958.
  25. Adami C. Physics of Life Reviews 1 (2004): 3-22.
×

Citation

Citation: Vidya Raghunathan. “How Common is Gain of Function”. Acta Scientific Microbiology 4.11 (2021): 30-34.




Metrics

Acceptance rate33%
Acceptance to publication20-30 days
Impact Factor0.810

Indexed In



News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is December 15, 2021.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US