Effect of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on Nonspecific Body Resistance, Immune System and Lipid Peroxidation Parameters
Pavel F Zabrodskii*
Saratov Medical University "REAVIZ", Saratov, Russia
*Corresponding Author: Pavel F Zabrodskii, Saratov Medical University "REAVIZ", Saratov, Russia.
Received: July 22, 2021 ; Published: August 05, 2021
In experiments on random-bred albino rats and CBA mice it was found that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TChDBD) induced a dose of 1.0; 4.0 and 8.0 µg/kg when administered single time. The main parameters of nonspecific body resistance (NBR), antibody formation mainly to the T-independent antigen, delayed-type hypersensitivity reactions (DTH) were dose-dependently reduced. TChDBD at the doses used had almost no effect on NK activity. Reduction of immune system parameters was directly related to the initiation of lipid peroxidation.
Keywords: Immune System; Lipid Peroxidation; Hypersensitivity Reactions (DTH)
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