Acta Scientific Microbiology (ISSN: 2581-3226)

Research Article Volume 4 Issue 9

Effect of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on Nonspecific Body Resistance, Immune System and Lipid Peroxidation Parameters

Pavel F Zabrodskii*

Saratov Medical University "REAVIZ", Saratov, Russia

*Corresponding Author: Pavel F Zabrodskii, Saratov Medical University "REAVIZ", Saratov, Russia.

Received: July 22, 2021 ; Published: August 05, 2021


In experiments on random-bred albino rats and CBA mice it was found that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TChDBD) induced a dose of 1.0; 4.0 and 8.0 µg/kg when administered single time. The main parameters of nonspecific body resistance (NBR), antibody formation mainly to the T-independent antigen, delayed-type hypersensitivity reactions (DTH) were dose-dependently reduced. TChDBD at the doses used had almost no effect on NK activity. Reduction of immune system parameters was directly related to the initiation of lipid peroxidation.

Keywords: Immune System; Lipid Peroxidation; Hypersensitivity Reactions (DTH)


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Citation: Pavel F Zabrodskii. “Effect of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on Nonspecific Body Resistance, Immune System and Lipid Peroxidation Parameters”. Acta Scientific Microbiology 4.9(2021): 23-27.


Copyright: © 2021 Pavel F Zabrodskii. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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