Acta Scientific Microbiology (ISSN: 2581-3226)

Research Article Volume 4 Issue 7

Novel Cyanoximate Pt (DECO)2 as an Anti-Cancer Drug Using ML1 Thyroid Cancer Cells

Rizvanovic Husref and Kim Kyoungtae*

Department of Biology, Missouri State University, Springfield, Missouri, USA

*Corresponding Author: Kim Kyoungtae, Department of Biology, Missouri State University, Springfield, Missouri, USA.

Received: May 20, 2021 ; Published: June 11, 2021

Abstract

Although current therapies for treating thyroid cancer offers good prognosis, there is an unmet need for better alternative anti-cancer drugs for treatment. Studies have shown that platinum based chemicals such as Cisplatin offer decent treatment options, but can also lead to severe side effects as well as develop a resistance. Given that cyanoximes are great ligands and that metals such as platinum offer good anti-proliferative and cytotoxic abilities, we investigated the role of a novel platinum-based cyanoximate in the treatment of thyroid cancer. Stage 4 thyroid cancer cell line, ML-1, was used in the present study to test the effects on cell viability and proliferation after treatment of Cisplatin and Pt(DECO)2. Changes in the levels of superoxide were also tested and compared with non-treated cells. Lastly, presentation of cell death was recorded after the treatment. After 24 hours of treatment at concentrations of 1.0 mM of Pt(DECO)2, we noticed drastic reduction in cell viability (F = 45.77, p < 0.0001), superoxide levels (F = 28.57, p = 0.0001), and an increase in cell death. These results suggest that this cyanoximate-induced cell death may work similarly to Cisplatin-based cell death. This in vitro study demonstrated the efficacy of the novel cyanoximate Pt(DECO)2 in treating thyroid cancer. Further studies are needed to delineate the effectiveness of this treatment in vivo and with other cancer cell lines.

Keywords: Cisplatin; Platinum; Pt(DECO)2; Thyroid Cancer; ML-1; Apoptosis; ROS; XTT

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Citation

Citation: Rizvanovic Husref and Kim Kyoungtae. “Novel Cyanoximate Pt (DECO)2 as an Anti-Cancer Drug Using ML1 Thyroid Cancer Cells”. Acta Scientific Microbiology 4.7 (2021): 50-56.

Copyright

Copyright: © 2021 Rizvanovic Husref and Kim Kyoungtae. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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