Pavel F Zabrodskii

Saratov Medical University "REAVIZ", Saratov, Russian Federation, Russia

*Corresponding Author: Pavel F Zabrodskii, Saratov Medical University "REAVIZ", Saratov, Russian Federation, Russia.

Received: May 14, 2021; Published: June 04, 2021

Citation: Pavel F Zabrodskii. “The Effects of α7n-Acetylcholine, β2-Adrenergic Receptors Agonists, NF-κB, STAT3 Inhibitors on the Implementation of the Cholinergic Anti-Inflammatory Pathway in Sepsis". Acta Scientific Microbiology 4.7 (2021): 16-20.

Abstract

  Experiments on random-bred albino mice showed that the administration of α7n-acetylcholine receptors agonist (GTS-21, 15 mg/kg), β2-adrenoreceptor agonist (dexmedetomidine hydrochloride, 25 μg/kg), NF-κB inhibitor (BAY 11-7082, 10 mg/kg) and STAT3 inhibitor (S3I-201, 15 mg/kg) to mice 2h before sepsis modeling (i.p, 2.5 × 109 CFUs diurnal culture of E. coli O157:H7) caused a significant reduction of mouse mortality at 4 and 24h after E. coli injection due to a decrease in the proinflammatory cytokines TNF-α, IL-1β and IL-6 (implementation of a cholinergic anti-inflammatory pathway). The effects of the preparations used did not differ significantly.

Keywords: Cholinergic Anti-inflammatory Pathway; Sepsis; Proinflammatory Cytokines; α7n-Acetylcholine Receptor; β2-Adrenoreceptor; NF-κB Inhibitor; STAT3 Inhibitor

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Copyright: © 2021 Pavel F Zabrodskii. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.