Can Targeting Gut Microbiota in Perinatal Events Aid in Prevention of Type 1 Diabetes Development - Influence T1D Genes Crosstalk with Environmental Factors
Kulvinder Kochar Kaur1*, Gautam Allahbadia2 and Mandeep Singh3
1Scientific Director, Dr Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India
2Scientific Director, Rotunda-A Centre for Human Reproduction, Mumbai, India
3Consultant Neurologist, Swami Satyan and Hospital, Jalandhar, Punjab, India
*Corresponding Author: Kulvinder Kochar Kaur, Scientific Director, Dr Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India.
Received: April 27, 2021 ; Published: June 04, 2021
Type 1 diabetes mellitus (T1D) represents a chronic autoimmune disease (AD) resulting from a complex interplay between genetic proneness and environmental factors. Mostly AD incidence follows a pattern of north-south, with escalated prevalence visualized in countries, such as Finland, Sweden as well as Norway. Gut Microbiota (GM) studies on the implications of extreme climatic environments (like antarctica, time of birth/venue, show impact of extreme cold conditions with no exposure to sunlight thus resulting in Vitamin D deficiency, influence GM composition and immune dysfunction. In case of population from north it is observed that circadian rhythm alterations occur and that have also been illustrated to =>immune dysfunction through a swing in the GM, resulting in AD like T1D [1-5].
- Kulvinder Kochar Kaur., et al. “An Update on Etiopathogenesis and Management of Type 1 Diabetes Mellitus”. Journal of Endocrinology2 (2017): 1-23.
- Kulvinder Kochar Kaur., et al. “Have Probiotics and Synbiotics passed the test of time to be implemented in management of obesity and related metabolic disorders-a comprehensive review”. Advances in Obesity, Weight Management and Control 1 (2019): 21-28.
- Kulvinder Kochar Kaur., et al. “Attempting Getting Insulin Independent Immunotherapies in Type 1 Diabetes Mellitus (T1D) in the Pre Stage 1 (BeforeIslet Autoantibodies)”. Acta Scientific Paediatrics6 (2020): 01-04.
- Kulvinder Kochar Kaur., et al. “Path Directed towards a Stage when we almost Cure Type1 Diabetes Mellitus (T1dm) after a Century of Insulin Advent”. EC Diabetes and Metabolic Research6 (2020): 37-46.
- Kulvinder Kochar Kaur., et al. “Are we any close to unraveling the mechanisms of interactions among Susceptibility genes towards type 1 Diabetes, Gut Microbiota along with Environmental factors –Specifically Early Diet patterns –A Systematic Review?” Endocrinology and Surgical Endocrinology1 (2021): 1-20.
- Walker WA. “The importance of appropriate initial colonization of the intestine in newborn, child, and adult health”. Paediatric Research 82 (2017): 387-395.
- Dominguez-Bello MG., et al. “Delivery mode shapes the initiation and structure of the initial Microbiata across multiple habitats in the newborn”. Proceedings of the National Academy of Sciences of the United States of America 107 (2010): 11971-11975.
- Cardwell CR., et al. “Caesarean section is associated with an increased risk of childhood onset- Type 1 diabetes: meta-analysis of observational studies”. Diabetologia 51 (2008): 726-735.
- Verduci E., et al. “Early nutrition and risk of Type1 Diabetes: the role of Type1 Diabetes”. Frontiers in Nutrition 7 (2020): 612377.
- Dedrick S., et al. “The role of Gut Microbiota and environmental factors in Type 1 diabetes pathogenesis”. Frontiers in Endocrinology 11 (2020): 78.
- Calabrese CM., et al. “Gut Microbiota and Type1 Diabetes”. Frontiers in Nutrition 7 (2020): 617223.
- Kahalehili HM., et al. “Dietary Indole-3-Carbinol Activates AhR in the Gut, Alters Th17-Microbe Interactions, and Exacerbates Insulitis in NOD Mice”. Frontiers in Immunology 11 (2020): 606441.
- Giampioli O., et al. “Can the FUT2 nonsecretory phenotype associated with Gut Microbiota increase the children susceptibility for Type1 Diabetes? A Minireview”. Frontiers in Nutrition 7 (2020): 606171.
- Elhag DA., et al. “Exploring the triple interaction between the Host Genome, the Epigenome and the Gut Microbiome in Type1 Diabetes”. International Journal of Molecular Sciences 22 (2021): 125.