Acta Scientific Microbiology (ISSN: 2581-3226)

Review Article Volume 4 Issue 6

Impact of Antiretroviral Treatment on the Plasmatic Viral Load of HIV-1 in Children Followed at the Charles de Gaulle Pediatric University Hospital (CHU-CDG), Ouagadougou Burkina Faso

Mahamoudou Sanou1,2,3,4,5*, Boureima Tangara2, Absatou BA3, Mamadou Tamboura2, Fidele Bakiono5, Bolni Marius Nagalo6, Benoit Kabamba7, Jacques Simpore4 and Rasmata Traore1,2

1University Joseph KI - ZERBO, Ouagadougou, Burkina Faso
2Pediatric University Hospital Charles De Gaulle, Ouagadougou, Burkina Faso
3University Hospital Bogodogo Ouagadougou, Burkina Faso
4Pietro Annigoni Biomolecular Research Center (CERBA), Department of Biochemistry - Microbiology, Burkina Faso
5Military hospital General Lamizana Ouagadougou, Burkina Faso
6Department of Hematology/Oncology, Mayo Clinic Scottsdale, AZ, USA
7AIDS Reference Laboratory, AIDS Reference Laboratory Catholic University of Louvain (UCL), Belgium

*Corresponding Author: Mahamoudou Sanou, University Joseph KI-ZERBO, Ouagadougou, Burkina Faso.

Received: March 03, 2021 ; Published: May 25, 2021


Introduction: Despite the improvement in the coverage and effectiveness of Prevention of Mother-to-Child Transmission of HIV (PMTCT) interventions, the pediatric epidemic of HIV infection still persists and the number of PLWHIV in Burkina Faso is estimated at the end of 2018 at 94,000, including 9,400 children under 15 years old.

Objective: The objective of this work is to contribute to better medical care for children under-15 living with HIV-1 by studying the impact of ART on virus replication, through the measurement of viral load ( VL).

Methodologies: This was a retrospective descriptive study carried out at Pediatric University Hospital Charles-de-Gaulle from January 1, 2016 to June 30, 2019. The study included all children under-15 infected with HIV type 1 (HIV-1) and with a plasma viral load measured in the Bacteriology-Virology Department during the study period.

Results: Out of a total of 811 children, 51% were boys, i.e. a sex ratio of 1.03 and nearly 80% of our patients came from the ESTHER project. The most represented age group was [10 - 15] years (50.06%). Among children, 47.3% had a treatment duration greater than or equal to 4 semesters and 43.2% had an undetectable plasma viral load after 4 semesters.

Keywords: HIV-1; PMTCT; Viral Load; ART; CHUP- CDG


  1. SP/CNLS-IST, ONUSIDA. Activity report on Burkina Faso's AIDS response (2013).
  2. DELFRAISY JF., Therapeutic management of people infected with HIV. Paris: Flammarion (2002): 342.
  3. SP/CNLS-IST, ONUSIDA. Activity report on Burkina Faso's AIDS response 2020 statistics on the state of the AIDS epidemic.
  4. TINTO S Mariéta. “Children on antiretroviral treatment at the Souro Sanou University Hospital in Bobo Dioulasso: incidence and associated factors”. [Thesis]: Universite NAZI Boni DE BOBO DIOULASSO (2013).
  5. Musoke PM., et al. “Growth, immune and viral responses in HIV infected African children receiving highly active antiretroviral therapy: a prospective cohort study”. BMC Pediatrics 10 (2010): 56.
  6. Mounerou Salou., et al. “High rates of virological failure and drug resistance in perinatally HIV-1-infected children and adolescents receiving lifelong antiretroviral therapy in routine clinics in Togo”. Journal of the International AIDS Society 19 (2016): 20683.
  7. Martin S., et al. “Patient, caregiver and regimen characteristics associated with adherence therapy among HIV-infected children and adolescents”. Pediatric Infectious Disease Journal 1 (2007): 61-67.
  8. Anude CJ., et al. “Immuno-virologic outcomes and immunovirologic discordance among adults alive and onanti-retroviral therapy at 12 months in Nigeria”. BMC Infectious Disease13 (2013): 113.
  9. Isaakidis P., et al. “High survival and treatment success sustained after two and three years of first line ART for children in Cambodia”. Journal of the International AIDS Society 13 (2010): 11.
  10. Szubert AJ and Prendergast AJ. “Virological response and resistance among HIV-infected children receiving long-term antiretroviral therapy without virological monitoring in Uganda and Zimbabwe: Observational analyses within the randomised ARROW trial”. November 14 (2017).
  11. Wamalwa DC., et al. “Long-Term Virologic Response and Genotypic Resistance Mutations in HIV-1 Infected Kenyan Children on Combination Antiretroviral Therapy”. Journal of Acquired Immune Deficiency Syndromes 3 (2013): 267-274.


Citation: Mahamoudou Sanou., et al. “Impact of Antiretroviral Treatment on the Plasmatic Viral Load of HIV-1 in Children Followed at the Charles de Gaulle Pediatric University Hospital (CHU-CDG), Ouagadougou Burkina Faso ”. Acta Scientific Microbiology 4.6 (2021): 87-90.


Copyright: © 2021 Mahamoudou Sanou., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate33%
Acceptance to publication20-30 days
Impact Factor0.614

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