Acta Scientific Microbiology (ISSN: 2581-3226)

Review Article Volume 4 Issue 6

Corona Virus Generated Pathogenesis, Antigenicity, Neurovirulence, and Host Immune Responses

Ravi Kant Upadhyay*

Department of Zoology, DDU Gorakhpur University, Gorakhpur, UP, India

*Corresponding Author: Ravi Kant Upadhyay, Department of Zoology, DDU Gorakhpur University, Gorakhpur, UP, India.

Received: April 22, 2021 ; Published: May 17, 2021


This article tries to draw attention of scientific community that coronavirus seems to be a laboratory manufactured virus. Since its outbreak in November 20202 corona virus has infected millions of people and caused thousands of deaths in the world. In a short span of 18 months, it has rapidly spread in more than 207 countries of the world. In all different climatic conditions virus multiplies in squared numbers, with an increase in fatalities and infectivity so far. Its double and triple mutants have appeared with infectivity and lethality, Virus has no effect of climatic conditions and seems thermal resistant; as it is showing almost similar mortality rate in cold countries as well as in warm countries. This is of great concern that reason that virus; behaving like a bio-weapon, much different that any natural virus. It is mutating at much faster rate. It is mutating like an artificial/recombinant/superimposed RNA virus particle and adjusting sequences accordingly in variable weather conditions. Recently its double mutant strains have been detected in large numbers of patients in India in five states. Though, for prophylactic use many vaccines have been generated whose success will depend on behavior of virus because it is highly mutating. It is still doubtful that existing vaccine will provide protection against fast spreading pandemic virus. Present paper is describing corona virus generated pathogenesis, antigenicity neurovirulence, and host immune responses. In this article few important suggestions have been given on virus transmission, pathogenesis, and development of immune responses, prophylaxis and vaccination. It is true that spread of Covid-19 pandemic occurred very fast and raised so many a political, socio-clinical therapeutic and economic issues.

Keywords: COVID-19; Pandemic; Infectivity; Mortality; Conventional Methods and Vaccine


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Citation: Ravi Kant Upadhyay. “Corona Virus Generated Pathogenesis, Antigenicity, Neurovirulence, and Host Immune Responses ”. Acta Scientific Microbiology 4.6 (2021): 53-69.


Copyright: © 2021 Ravi Kant Upadhyay. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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