F Haddad, H Lahssini*, Z Boukhal, Fz El Rhaoussi, M Tahiri, W Hliwa, A Bellabeh and W Badre

Gastroenterology Department, Ibn Rochd University Hospital, Casablanca, Morocco

*Corresponding Author: H Lahssini, Gastroenterology Department, Ibn Rochd University Hospital, Casablanca, Morocco.

Received: November 20, 2025; Published: November 27, 2025

Abstract

Celiac disease is a chronic autoimmune enteropathy triggered by gluten ingestion in genetically predisposed individuals. It is characterized by small-intestinal villous atrophy leading to malabsorption and may present with numerous extraintestinal manifestations, particularly hepatic ones. Although uncommon, the association between celiac disease and liver cirrhosis is often overlooked. Its recognition is crucial, as adherence to a gluten-free diet can lead to significant improvement in liver function and overall prognosis.

Case Presentation: We report the case of a 65-year-old female patient followed for cryptogenic cirrhosis, complicated by ascites and variceal bleeding. She also presented chronic abdominal pain and recurrent watery diarrhea. The IgA anti-transglutaminase antibodies were strongly positive at 300 IU/mL. Upper endoscopy showed partial disappearance of duodenal folds, and biopsies confirmed celiac disease. The patient was started on a strict gluten-free diet with marked improvement during follow-up. Our case stresses the importance of considering celiac disease in cryptogenic cirrhosis, as early detection may modify the outcome.

Keywords: Celiac Disease; Cryptogenic Cirrhosis; Gluten-Free Diet; Autoimmune Enteropathy; Malabsorption

References

1. Ludvigsson JF., et al. “Celiac disease and risk of liver disease: a general population-based study”. Clinical Gastroenterology and Hepatology1 (2007): 63-69.
2. Peters U., et al. “Causes of death in patients with celiac disease in a population-based Swedish cohort”. Archives of Internal Medicine13 (2003): 1566-1572.
3. Prasad KK., et al. “Celiac disease and the liver: spectrum of hepatic abnormalities in celiac disease and effect of gluten-free diet in treatment”. Indian Journal of Gastroenterology1 (2013): 40-46.
4. Rubio-Tapia A and Murray JA. “The liver in celiac disease”. Hepatology5 (2007): 1650-1658.
5. Tovoli F., et al. “Increased Risk of Nonalcoholic Fatty Liver Disease in Patients with Coeliac Disease on a Gluten-Free Diet: Beyond Traditional Metabolic Factors”. Alimentary Pharmacology and Therapeutics5 (2018): 538-546.

Citation

Citation: H Lahssini., et al. “Cryptogenic Cirrhosis Revealing Celiac Disease: A Case Report".Acta Scientific Gastrointestinal Disorders 8.12 (2025): 10-12.

Copyright

Copyright: © 2025 H Lahssini., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.