VM Smirnov¹*, DS Sveshnikov² and AV Kuchuk³

¹Doctor of Medical Sciences, Professor, Department of Physiology, Pirogov Russian National Research Medical University (RNRMU), Moscow, Russia
²Doctor of Medical Sciences, Professor, Department of Physiology, Peoples' Friendship University of Russia (RUDN University), Moscow, Russia
³Candidate of Medical Sciences, Associate Professor of the Department of Anatomy of the Peoples' Friendship University of Russia

*Corresponding Author: VM Smirnov, Doctor of Medical Sciences, Professor, Department of Physiology, Pirogov Russian National Research Medical University (RNRMU), Moscow, Russia.

Received: March 19, 2025; Published:April 13, 2025

Abstract

Purpose of the Study: Study of the role of adrenoceptors in the implementation of the stimulatory effect of serotonin (as a mediator of serotonergic nerves) on the motility of the large intestine.

Materials and Methods: The experiments were carried out on rats (27) of the Wistar line under the conditions of the surgical stage of anesthesia. Electromyogram and hydrostatic pressure in the colonic cavity were recorded using a Masintosh Performa 6400/180 computer and the Chart 4.2.3 program.

Serotonin was injected into the body of intact animals and against the background of separate and joint blockade of α- and β-adrenergic receptors.

Results of the Study: In experiments on rats, it was found that preliminary simultaneous blockade of α- and β-adrenergic receptors leads to an increase in the stimulatory effect of the colon when serotonin is administered by 353%, blockade of only α-adrenergic receptors - by 331%, blockade of β-adrenergic receptors - by 265%. In intact animals, the stimulant effect of serotonin is +170%. Simultaneous and separate blockade of α- and β-adrenergic receptors without serotonin administration is accompanied by a weakening of colonic contractions by 14-19%.

Inference: Intact α- and β-adrenergic receptors interfere with the stimulatory effect of serotonin on toast motility

Keywords: Large Intestine, Motility, Serotonin, α- and β- Adrenoceptors

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Citation

Citation: VM Smirnov., et al. “The Mechanism of Adrenoceptors Interfering with the Stimulating Effect of Serotonin on Colonic Contractions".Acta Scientific Gastrointestinal Disorders 8.5 (2025): 14-19.

Copyright

Copyright: © 2025 VM Smirnov., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.