Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Editorial Volume 7 Issue 3

Callow and Naive-Juvenile Granulosa Cell Tumour Testis

Anubha Bajaj*

Department of Histopathology, Panjab University, India

*Corresponding Author: Anubha Bajaj, Department of Histopathology, Panjab University, India.

Received: January 17, 2024; Published: February 01, 2024

Abstract

Juvenile granulosa cell tumour is an exceptionally discerned neoplasm engendered from specialized gonadal stromal cells or primitive granulosa cells wherein testicular lesion is preponderantly unilateral and encountered within 6 months of neonatal period. Testicular juvenile granulosa cell tumour is associated with anomalous karyotype or genetic mosaics such as chromosome 45, X/47, XXY, 45X/46 or X.r(Y). Neoplasm is concordant with testicular cryptorchidism or dysgenetic gonads as a component of Drash syndrome. Tumefaction demonstrates solid, nodular or follicular configurations or an admixture of aforesaid patterns. Neoplastic cells are pervaded with moderate to abundant, pale to eosinophilic cytoplasm and spherical to ovoid, hyperchromatic nuclei with significant mitotic activity. Extensive stromal hyalinization is associated with myxoid substance within intervening stroma. Tumour cells are immune reactive to FOXL2, steroidogenic factor 1 (SF1), vimentin, inhibin, calretinin, Wilm’s tumour 1 (WT1) antigen and SOX9. Testicular juvenile granulosa cell tumour requires segregation from neoplasms such as yolk sac tumour, teratoma, cystic dysplasia of the testicle, Sertoli cell tumour, gonadoblastoma, unclassified sex cord stromal tumours or testicular rhabdomyosarcoma. Surgical manoeuvers as orchiectomy or intervention techniques as testis sparing surgical modalities appropriately alleviate the neoplasm.

Keywords: Juvenile; Genetic Mosaicism; Gonadal Stromal Cells

References

  1. Collins K., et al. “Testicular Juvenile Granulosa Cell Tumors Demonstrate Recurrent Loss of Chromosome 10 and Absence of Molecular Alterations Described in Ovarian Counterparts”. Modern Pathology 6 (2023): 100142.
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  4. Michalova K., et al. “Novel insights into the mixed germ cell-sex cord stromal tumor of the testis: detection of chromosomal aneuploidy and further morphological evidence supporting the neoplastic nature of the germ cell component”. Virchows Archiv 5 (2020): 615-623.
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  7. Kao CS., et al. “Juvenile granulosa cell tumors of the testis: a clinicopathologic study of 70 cases with emphasis on its wide morphologic spectrum”. The American Journal of Surgical Pathology 9 (2015): 1159-1169.
  8. Image 1 Courtesy: Wikimedia commons
  9. Image 2 Courtesy: Science direct

Citation

Citation: Anubha Bajaj. “Callow and Naive-Juvenile Granulosa Cell Tumour Testis". Acta Scientific Gastrointestinal Disorders 7.2 (2024): 01-04.

Copyright

Copyright: © 2024 Anubha Bajaj. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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