VM Smirnov¹*, DS Sveshnikov² and AV Kuchuk³

¹Doctor of Biological Sciences, Professor, Department of Physiology, Pirogov Russian National Research Medical University (RNRMU), Moscow, Russia
²Doctor of Medical Sciences, Professor, Department of Physiology, Peoples' Friendship University of Russia (RUDN), Moscow, Russia
³Ph.D., Assistant of the Department of Anatomy, RUDN University, Moscow, Russia

*Corresponding Author: VM Smirnov; Doctor of Biological Sciences, Professor, Department of Physiology, Pirogov Russian National Research Medical University (RNRMU), Moscow, Russia.

Received: April 27, 2023; Published: October 04, 2023

Abstract

The aim of the study: Was to elucidate the role of cholinergic receptors in the stimulating effect of serotonin on gastric motility.

Materials and methods: The studies were performed on sexually mature Wistar rats on an empty stomach under the conditions of the whole organism in the surgical stage of anesthesia (nembutal, 60 mg/kg intramuscularly). The electromyogram and hydrostaticpressure in the gastric cavity were recorded using the BioAmp ML132 amplifier (Adinstruments, Australia), the Maclab 8e analog-to-digital converter (Adinstruments, Australia), the Macintosh Performa 6400/180 computer and the Chart 4.2.3 program.

Results and Discussion: It was found that the preliminary blockade of N-choli noreceptors leads to an increase in the stimulating effect of the stomach on the introduction of serotonin by 40%, in conditions of blockade of M-cholinergic receptors - by 56%. The blockade of N-cholinergic receptors itself increased the strength of gastric contractions by 32%, while a separate blockade of M-cholinergic receptors was not accompanied by a change in the strength of gastric contractions.

Conclusion: The weakening of the stimulating effect of serotonin on gastric motility with the help of N- and M-cholinergic receptors is carried out through the activation of adrengic and VIPergic inhibitory neurons.

Keywords: Stomach; Motility; Serotonin; M- and N-cholinergic receptors

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Citation

Citation: VM Smirnov., et al. “The Role of Cholinergic Receptors in the Implementation of the Stimulating Effect of Serotonin on the Stomach".Acta Scientific Gastrointestinal Disorders 6.11 (2023): 03-07.

Copyright

Copyright: © 2023 VM Smirnov., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.