Anubha Bajaj*

Department of Histopathology, Panjab University/A.B. Diagnostics, India

*Corresponding Author: Anubha Bajaj, Department of Histopathology, Panjab University/A.B. Diagnostics, India.

Received: June 22, 2023; Published: July 21, 2023

Abstract

Splenic diffuse red pulp small B cell lymphoma is a mature splenic B cell lymphoma characterized by diffuse infiltration of splenic red pulp with miniature, monomorphic B lymphocytes and configures as a provisional entity of splenic B cell lymphoma/leukaemia, unclassifiable within the contemporary WHO classification of lymphomas. Neoplastic cells depict a villous morphology and appear to invade sinusoids of bone marrow and peripheral blood. Lymphoma is determined as stage IV disease with incrimination of spleen, bone marrow and peripheral blood. Segregation from disorders such as hairy cell leukaemia, hairy cell leukaemia variant and splenic marginal zone lymphoma is necessitated. Median age of disease emergence appears at 65.5 years to 77 years. A male predominance is observed with male to female proportion of 1.6 to 2.4:1. Splenic diffuse red pulp small B cell lymphoma demonstrates chromosomal del 7(q), partial trisomy 3q, trisomy 18 or del 17p. Peripheral smear exhibits miniature, villous lymphocytes with basophilic cytoplasm, clumped nuclear chromatin, smooth nuclear outline and a polar distribution of broad cytoplasmic extensions. Cytological examination delineates monomorphic, miniature to intermediate lymphocytes imbued with spherical to elliptical nuclei with compact, clumped nuclear chromatin and occasional, distinct, miniature nucleoli. Morphologically, spleen delineates diffuse incrimination of red pulp cords and sinusoids by monomorphic lymphoma cells. Bone marrow exhibits an intra-sinusoidal pattern of tumour infiltration. Minimal lymphocytosis, thrombocytopenia or leukopenia is observed. Splenic diffuse red pulp small B cell lymphoma appears immune reactive to CD20, PAX5, CD79a and DBA-44. Segregation from hairy cell leukaemia, hairy cell leukaemia variant or splenic marginal zone lymphoma is necessitated. Rituximab may be beneficially employed for cogent therapy.

 Keywords: Leukaemia; World Health Organization (WHO)

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9. Image 1 Courtesy: Haematologica.com
10. Image 2 Courtesy: Hindawi.com

Citation

Citation: Anubha Bajaj. “The Blushing Broadcast-Splenic Diffuse Red Pulp Small B Cell Lymphoma". Acta Scientific Gastrointestinal Disorders 6.8 (2023): 26-29.

Copyright

Copyright: © 2023 Anubha Bajaj. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.