Intestinal Adenocarcinoma in Biopsy-Defined Celiac Disease
Hugh James Freeman*
Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, BC, Canada
*Corresponding Author: Hugh James Freeman, Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, BC, Canada.
January 05, 2023; Published:
January 20, 2023
Different intestinal malignancies develop in celiac disease, particularly lymphoma. In this study, the records of 154 patients with celiac disease followed during a 30 year period with an initial small bowel biopsy and a histopathological response to a gluten-free diet were retrospectively reviewed for development of adenocarcinoma. Four males were observed with a small bowel adenocarcinoma as well as 1 elderly female with colon cancer. Other sites, including esophagus, stomach, hepatobiliary tract and pancreas, had no adenocarcinomas detected. Patients with biopsy-defined celiac disease had an increased rate of small bowel adenocarcinoma, at least in males, but a reduced rate of colonic adenocarcinoma. These long-term clinical results from published studies in a well-defined population of celiac disease have important implications for further investigative endeavour related to celiac disease and intestinal malignancies.
Celiac Disease; Small Bowel Cancer; Colon Cancer; Epithelial Carcinogenesis; Gluten-free Diet; Cancer Enteropathy
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