Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Mini Review Volume 6 Issue 2

Intestinal Adenocarcinoma in Biopsy-Defined Celiac Disease

Hugh James Freeman*

Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, BC, Canada

*Corresponding Author: Hugh James Freeman, Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, BC, Canada.

Received: January 05, 2023; Published: January 20, 2023


Different intestinal malignancies develop in celiac disease, particularly lymphoma. In this study, the records of 154 patients with celiac disease followed during a 30 year period with an initial small bowel biopsy and a histopathological response to a gluten-free diet were retrospectively reviewed for development of adenocarcinoma. Four males were observed with a small bowel adenocarcinoma as well as 1 elderly female with colon cancer. Other sites, including esophagus, stomach, hepatobiliary tract and pancreas, had no adenocarcinomas detected. Patients with biopsy-defined celiac disease had an increased rate of small bowel adenocarcinoma, at least in males, but a reduced rate of colonic adenocarcinoma. These long-term clinical results from published studies in a well-defined population of celiac disease have important implications for further investigative endeavour related to celiac disease and intestinal malignancies.

Celiac Disease; Small Bowel Cancer; Colon Cancer; Epithelial Carcinogenesis; Gluten-free Diet; Cancer Enteropathy


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Citation: Hugh James Freeman. “Intestinal Adenocarcinoma in Biopsy-Defined Celiac Disease". Acta Scientific Gastrointestinal Disorders 6.2 (2023): 16-18.


Copyright: © 2022 Hugh James Freeman. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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