Paul H Hartel¹* and Denise Davey²

¹Department of Pathology, Sligo University Hospital and NUI Galway School of Medicine, Ireland and W. Virginia University School of Medicine, USA

*Corresponding Author: Paul H Hartel, Department of Pathology, Sligo University Hospital and NUI Galway School of Medicine, Ireland and W. Virginia University School of Medicine, USA.

Received: October 03, 2022; Published: October 26, 2022

Abstract

Extracapsular lymph node tumour extension (ETE) from lymph nodes with metastatic cancer is a known negative prognostic indicator in several tumours, including colon cancer. Conversely, robust tumour-inflammatory response has been associated with favourable prognoses. We evaluated extracapsular extension of lymph node metastatic tumour in colon cancer to further study its association with clinical and histopathologic variables, and specifically, tumour-inflammatory response such as tumour-infiltrating lymphocytes and Crohn-like lymphoid reaction. We found that, compared to colon tumour cases without ETE, colon tumours with ETE occurred in younger patients, and had a higher prevalence of poorly differentiated tumours and higher tumour stage. They also had more positive lymph nodes, and more venous and perineural tumour invasion. In contrast, colon tumour cases with ETE had less Crohn-like lymphoid reaction and less tumour infiltrating lymphocytes. These findings suggest that colon tumours with ETE are inherently more biologically aggressive and are associated with less tumour-inflammatory response. Immunotherapies that bolster immune-mediated destruction of tumour cells may mitigate the negative prognostic factors associated with ETE and may be a potentially useful treatment adjunct to improve patient outcomes in this patient population. 

Keywords: Extranodal Extension; Colon Cancer; Prognostic Indicators; Tumor-inflammatory Response; Tumor Infiltrating Lymphocytes; Crohn-like Lymphoid Reaction

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Citation

Citation: Paul H Hartel and Denise Davey. “Extracapsular Lymph Node Tumour Extension is a Potential Biomarker for Immune-modulating Therapy in Colon Cancer". Acta Scientific Gastrointestinal Disorders 5.11 (2022): 31-34.

Copyright

Copyright: © 2022 Paul H Hartel and Denise Davey. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.