Roman Yanko*, Mikhail Levashov and Olena Chaka

Department of Clinical Physiology of Connective Tissue, Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine, Ukraine

*Corresponding Author: Roman Yanko, Department of Clinical Physiology of Connective Tissue, Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine, Ukraine.

Received: September 15, 2022; Published: October 20, 2022

Abstract

Aim: To compare of histo-morphological disorders of the pancreas in rats of different ages with alimentary-induced obesity.

Materials and Methods: The study was conducted on the male Wistar rats aged 6 and 21 months. Alimentary obesity was modeled by feeding the animals a high-calorie diet (580 kcal/100 g) with an excess of fats and carbohydrates for 12 weeks. The control animals received the standard diet (330 kcal/100 g). Histological preparations were made from the pancreas tissue. Histo-morphometry was carried out using the computer program "ImageJ". The concentration of glucose, lipids and cholesterol in the blood serum of rats was determined.

Results: It was revealed that a high-calorie diet led to the development of alimentary obesity and the appearance of pronounced signs of pancreatic hypofunction in experimental rats. The intensity of histo-morphological disorders of the pancreas depended on the age and degree of animal’s obesity. These changes were more pronounced in young rats. The endocrine function of the pancreas underwent more negative changes in obesity than exocrine.

Conclusion: The results obtained are important for practical medicine in resolving the treatment and prevention of pancreas diseases in obesity patients of different ages.

Keywords: Alimentary Obesity; High-calorie Diet; Pancreas; Histo-morphometry; Age

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Citation

Citation: Roman Yanko., et al. “Morpho-functional Features of the Pancreas in Different Ages Rats with Alimentary Obesity". Acta Scientific Gastrointestinal Disorders 5.11 (2022): 03-09.

Copyright

Copyright: © 2022 Roman Yanko., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.