Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Research Article Volume 5 Issue 9

Kidney Manifestations in Chronic Hepatitis C

Sander BQ*, Veríssimo AR, Maiolini R, Maiolini CPTB, Siqueira RS, Tomazelli LJ, Rezende FA, Tinoco NB, Alvariz ES, Tosta Jr FV, Vidal MFP, Portela E, Neto e Silva GJT, Daghastanli AA, Fraga MG, Palma LGR, Coila WC, Daud BJDD, Nóbrega G, Silva M, Lobato ICCC, Povoa N, Gonçalves DM, Silva Neto FM, Dias MF, Rocha LVD, Espirito Santo BCC and Machado AEV

Professor of Gastroenterology of AproMed Consultant, Upper GI and Bariatric Endoscopy, Medical Director, Endoscopy Offices, Sander Medical Center - Day Hospital, Brazil

*Corresponding Author: Sander BQ, Professor of Gastroenterology of AproMed Consultant, Upper GI and Bariatric Endoscopy, Medical Director, Endoscopy Offices, Sander Medical Center - Day Hospital, Brazil.

Received: August 16, 2022; Published: August 19, 2022


Introduction: Hepatitis C is a worldwide health problem. Between 1999 and 2017 there are 587,821 confirmed cases of viral hepatitis in Brazil with the following distribution: Hepatitis A: 164,892 (28.0%); Hepatitis B: 218,257 (37.1%); Hepatitis C: 200,839 (34.2%); Hepatitis D: 3,833 (0.7%). An association between hepatitis C virus (HCV) infection and mixed cryoglobulimeia in renal disease has been described with type I membranoproliferative glomerulonephritid being the most common renal impairment. Hepatitis C is a disease caused by the Hepatitis C virus, a flaviviridae RNA virus. HCV was identified by Choo and colleagues in 1989 in the United States. This condition is a major cause of liver-related morbidity, accounting for over 1 million deaths as a result of cirrhosis and hepatocarcinoma. It has a chronic and insidious character.

Objective: To report and discuss information from scientific articles that directly or indirectly treat renal manifestations in patients with chronic hepatitis c. 

Methods: A bibliographic search was performed in the Pubmed database using two different capture strategies, which involved the use of the “MeSH Database” tool applying in the search field the terms: " Hepatitis C " and " chronic Kidney disease " and the “Related Articles” tool. The articles captured by both strategies were considered for reading, as well as the articles cited in their bibliographic references.

Conclusions: After careful reading of the selected articles, it can be seen that the established and direct relationship between hepatitis C and chronic renal failure, particularly pseudomembranous glomerulonephrephritis due to cryoglobulin deposition. It was clear that chronic kidney disease, especially dialysis, is at increased risk for hepatitis C virus infection and, in addition, patients with chronic hepatitis C have as one of the extrahepatic manifestations the chronic kidney disease due to cryoglobulinemia.


Keywords: Hepatitis C; Chronic Kidney Disease (CKD); Membranoproliferative Glomerulonephritis (MPGN)


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Citation: Sander BQ., et al. “Kidney Manifestations in Chronic Hepatitis C". Acta Scientific Gastrointestinal Disorders 5.9 (2022): 20-25.


Copyright: © 2022 Sander BQ., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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