IS Grekov¹* and EA Seleznyov²*

¹State Educational Institution, Donetsk National Medical University M. Gorky, Donetsk, Ukraine
²State Budgetary Institution Amvrosievsky Central Hospital, Mordovia Republic, Russia

*Corresponding Author: IS Grekov, State Educational Institution, Donetsk National Medical University M. Gorky, Donetsk, Ukraine.

Received: June 09, 2022; Published: July 29, 2022

Abstract

At present, the study of the characteristics of tumor vessels is of great interest for understanding the patterns of tumor growth, and in practical terms, it makes it possible, taking into account the characteristics of the blood supply, to identify prognosis criteria and choose the optimal type of therapeutic measures, including the suppression of angiogenesis.

Tumor vessels differ from normal vessels in their distribution, structure, and function. Features of the morphology of blood and lymph vessels affect the invasiveness, metastasis of the tumor and the prognosis of the disease. Much attention is now paid to the differences between lymphatic vessels and blood capillaries under light microscopy. There is evidence that high lymphatic density is associated with lymph node metastases and worse patient survival, particularly in gastric cancer. Therefore, scientific developments are aimed at determining specific markers for both the endothelium of the lymphatic and blood vessels, which will further help in the timely diagnosis of the pathological process.

Keywords: Epithelial-Mesenchymal Transformation; Angiogenesis; Gastric Cancer; Diagnostics; Immunohistochemistry

References

1. Vasilenko IV., et al. “Epithelial-mesenchymal transition in main types of gastric carcinoma”. American Journal of Translational Research 10 (2 (2021): 13-
2. Nakamura Y., et al. “Importance of lymph vessel in gastric cancer: a prognostic indicator in general and a predictor for lymph node metastasis in early-stage cancer”. Journal of Clinical Pathology 59 (2006): 77-82.
3. Dimmelar S and Zeiher A. “Phosphorilation of the endothelial nitric oxide synthase at Ser-1177 is required for VEGF-induced endothelial cell migration”. FEBC Letters 477 (2000): 23-62.
4. McDonald D and Beluk P. “Significance of blood vessel leakiness in cancer”. Cancer Research 62.15 (2002): 5381-5385.
5. Dvorak HF. “How tumors make bad blood vessels and stroma”. The American Journal of Pathology 162.6 (2003): 1747-1757.
6. Roberts WG., et al. “Host microvasculature influence on tumor vascular morfology and endothelial gene expression”. The American Journal of Pathology 153 (1998): 1239-1248.
7. Ye-Jiang Zhou., et al. “Inactivation of PTEN is associated with increased angiogenesis and VEGF overexpression in gastric cancer”. World Journal of Gastroenterology 10.21 (2004): 3225-3229.
8. Lucchi J., et al. European Journal of Cardio-Thoracic Surgery 12.7 (1997): 535- 541.
9. Miao HQ., et al. “Neuropilin-1 expressionby tumor cells promotes tumor angiogenesis and progression”. The EMBO Journal 14 (2000): 2532-2539.
10. Yancopoulos G., et al. “Vascular-specific growth factors and blood vessel formation”. Nature 407 (2000): 242-248.

Citation

Citation: IS Grekov and EA Seleznyov. “Some Aspects of Angiogenesis of the Main forms of Gastric Cancer".Acta Scientific Gastrointestinal Disorders 5.8 (2022): 52-57.

Copyright

Copyright: © 2022 IS Grekov and EA Seleznyov. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.