Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Research Article Volume 5 Issue 8

Colonic Lymphoid Aggregate Histology Is Associated with Gut Microbial Flora Content in Symptomatic Patients with Normal Colonoscopy

Chiara Del Greco1 and Paul H Hartel2*

1Department of Biomedical Sciences, Atlantic Technological University, Ireland
2Department of Pathology, Sligo University Hospital, Ireland

*Corresponding Author: Paul H Department of Pathology, Sligo University Hospital, Ireland.

Received: July 11, 2022; Published:

Abstract

Colonic lymphoid aggregates in patients without colonic pathology and normal colonoscopic findings have been associated with persistent diarrhoea in a subset of patients. These lymphoid aggregates are not consistently reported by pathologists. We evaluated lymphoid aggregates in 40 symptomatic patients from otherwise normal colonic biopsies with normal colonoscopy findings to determine the relationship between clinical and pathologic parameters including any associations with normal colonic microbial flora. We found that the presence of gram-negative cocci, short bacilli and long bacilli were associated with larger more well-circumscribed lymphoid aggregates than other microbial flora combinations. For some patients, specific colonic microbial flora content may be associated with lymphoid response and symptoms.

 

Keywords: Colon; Lymphoid Aggregates; Diarrhoea; Gut Flora; Gram-Negative Bacteria

References

  1. Shah N., et al. “Lymphocytic follicles and aggregates are a determinant of mucosal damage and duration of diarrhoea”. Archives of Pathology and Laboratory Medicine1 (2013): 83-89.
  2. Mai V., et al. “Colonic Bacterial Flora: Changing Understandings in the Molecular Age”. The Journal of Nutrition2 (2004): 459-464.
  3. Guo P., et al. “Clostridium species as probiotics: potentials and challenges”. Journal of Animal Science and Biotechnology11 (2020):24.
  4. Navaneethan U., et al. “Mechanisms of infectious diarrhea”. Nature Clinical Practice. Gastroenterology and Hepatology11 (2008): 637-647.
  5. Salyers A.A., et al. “Gram-Negative Opportunistic Anaerobes”. Friends and Foes. in M. Schaechter (ed.) Encyclopedia of Microbiology (Third Edition). Oxford: Academic Press (2009): 145-152.
  6. Musch M.W., et al. “T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase”. The Journal of Clinical Investigation11 (2002): 1739-1747.
  7. Thadepalli H., et al. “Microflora of the human small intestine”. American Journal of Surgery6 (1979): 845-850.

Citation

Citation: Chiara Del Greco and Paul H Hartel. “Colonic Lymphoid Aggregate Histology Is Associated with Gut Microbial Flora Content in Symptomatic Patients with Normal Colonoscopy". Acta Scientific Gastrointestinal Disorders 5.8 (2022): 44-47.

Copyright

Copyright: © 2022 Chiara Del Greco and Paul H Hartel. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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